Correlation of FOXP3 Expression in Placenta as Regulatory T Cells Marker with Maternal HBeAg Serum and Intrauterine Transmission Status

Authors

  • Anggreiny Iwisara
  • Rina Masadah
  • Berti J Nelwan
  • Maisuri Tajuddin Chalid
  • Ni Ketut Sungowati
  • Gunawan Arsyadi
  • Andi Alfian Zainuddin
  • Upik Anderiani Miskad Faculty of Medicine, Hasanuddin University

Keywords:

Keywords, Hepatitis B, HBsAg, HBeAg, FOXP3, Regulatory T cell, Intrauterine Transmission, HBV DNA

Abstract

Hepatitis B is an infectious disease caused by the Hepatitis B Virus (HBV) with a risk of transplacental (mother-to-child) transmission which is responsible for the failure of child

Author Biography

Upik Anderiani Miskad, Faculty of Medicine, Hasanuddin University

DEPARTMENT OF PATHOLOGY,

References

Navabakhsh B, Mehrabi N, Estakhri A, Mohamadnejad M, Poustchi H. Hepatitis B Virus Infection during Pregnancy: Transmission and Prevention. Middle East J Dig Dis [Internet]. 2011;3(2):92

Voiculescu M. How far we are towards eradication of HBV infection. J Gastrointest Liver Dis. 2015;24(4):473

Tang LSY, Covert E, Wilson E, Kottilil S. Chronic Hepatitis B Infection. Jama [Internet]. 2018;319(17):1802.

Sarpel D, Kushner T, Carter D, Huisman T, Chiu S, Dieterich D. Mother-To-child transmission of hepatitis B and C virus: Review of the epidemiology and current treatment options. Future Virol. 2018;13(1):43

Trehanpati N, Hissar S, Shrivastav S, Sarin SK. Immunological mechanisms of hepatitis B virus persistence in newborns. Indian J Med Res [Internet]. 2013;138(5):700

Vyas AK, Jindal A, Hissar S, Ramakrishna G, Trehanpati N. Immune balance in Hepatitis B Infection: Present and Future Therapies. Scand J Immunol. 2017;86(1):4

Nelson NP, Jamieson DJ, Murphy T V. Prevention of perinatal hepatitis B virus transmission. J Pediatric Infect Dis Soc. 2014;3(SUPPL1):7

Liu J, Feng Y, Wang J, Li X, Lei C, Jin D, et al. An

Li Z, Hou X, Cao G. Is mother-to-infant transmission the most important factor for persistent HBV infection? Emerg Microbes Infect. 2015;4(5).

Shrivastava S, Trehanpati N, Patra S, Kottilil S, Pande C, Trivedi SS, et al. Increased regulatory T cells and impaired functions of circulating CD8 T lymphocytes is associated with viral persistence in Hepatitis B virus-positive newborns. J Viral Hepat. 2013;20(8):582

Hao HY et all. Relationship between HBeAg from HBsAg positive mothers and its influence on HBV intrauterine transmission. PubMed. 2017;38(10):1410

Tran TT. Immune tolerant hepatitis B: A clinical dilemma. Gastroenterol Hepatol. 2011;7(8):511

Pereira LMS, Gomes STM, Ishak R, Vallinoto ACR. Regulatory T cell and forkhead box protein 3 as modulators of immune homeostasis. Front Immunol. 2017;8(MAY):1

Li W, Han J, Wu H. Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression. Chronic Dis Transl Med [Internet]. 2016;2(2):67

Chen X, Gan T, Liao Z, Chen S, Xiao J. Foxp3 (-/ATT) Polymorphism Contributes to the Susceptibility of Preeclampsia. PLoS One. 2013;8(4).

Abdi F. Hepatitis B and pregnancy: An update review article. World J Obstet Gynecol [Internet]. 2015;4(1):1.

Wu C, Hsu T, Kung F, Changchien C, Tsai C, Lu S. Changes in the Prevalence of HBsAg and HBeAg : a Study of 8696 Parturients in a Well Vaccinated Area. Sci Rep [Internet]. 2017;(March):1

Tran TT, Gordon SC, Fung S, Dinh P, Yee L, Martins B, et al. Hepatitis B e Antigen Status and Hepatitis B DNA Levels in Women of Childbearing Age with Chronic Hepatitis B Infection Screening for Clinical Trials. 2015;1

Amsalu A, Ferede G, Eshetie S, Tadewos A, Assegu D. Prevalence, Infectivity, and Associated Risk Factors of Hepatitis B Virus among Pregnant Women in Yirgalem Hospital, Ethiopia : Implication of Screening to Control Mother-to-Child Transmission. 2018;2018.

Luuse A, Dassah S, Lokpo S, Ameke L, Noagbe M, Adatara P, et al. Sero-prevalence of Hepatitis B surface antigen amongst on commercial use on. 2016;7:10

Hu X, Wang Y, Mor G, Liao A. Forkhead box P3 is selectively expressed in human trophoblasts and decreased in recurrent pregnancy loss. Placenta [Internet]. 2019;81(13):1

Pereira LMS, Gra

Erkers T, Stikvoort A, Uhlin M. Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy. Stem Cells Int. 2017;2017.

Rowe JH, Ertelt JM, Xin L, Way SS. Regulatory T cells and the immune pathogenesis of prenatal infection. Reproduction. 2013;146(6).

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Published

2019-08-14

How to Cite

Iwisara, A., Masadah, R., J Nelwan, B., Tajuddin Chalid, M., Sungowati, N. K., Arsyadi, G., Alfian Zainuddin, A., & Miskad, U. A. (2019). Correlation of FOXP3 Expression in Placenta as Regulatory T Cells Marker with Maternal HBeAg Serum and Intrauterine Transmission Status. International Journal of Sciences: Basic and Applied Research (IJSBAR), 48(1), 85–92. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/10221

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