Association of Fibrinogen and Neutrophil Levels with Incidence and Severity of Chronic Obstructive Pulmonary Disease

  • Muhammad Ilyas Division of Pulmonary Medicine, Department of Internal Medicine, Medicine Faculty, Hasanuddin University
Keywords: COPD, neutrophil, fibrinogen, COPD severity


The major characteristic of COPD is systemic inflammation. This inflammatory process stimulates hematopoietic system, especially bone marrow, to release leukocytes and stimulates the liver to produce acute-phase proteins such as fibrinogen. Fibrinogen levels tend to increase with severe airflow obstruction. High neutrophil levels are associated with a decrease in FEV1 even beyond exacerbations. In this study, we evaluated the relationship between fibrinogen and neutrophil levels with severity of COPD. The objective of this study was to analyze the correlation between fibrinogen and neutrophil levels with the incidence and severity of COPD. Design of this study was observational with a cross-sectional approach to population of COPD patients from May to July 2017 and healthy people as control. Consecutive sampling did a sampling of COPD patients. We evaluated clinical, CAT score, history of exacerbations, number of cigarettes consumed, fibrinogen, and neutrophil levels. From 35 COPD subjects and 21 healthy controls, we found that fibrinogen and neutrophils levels increased in COPD subjects compared to control (p <0.001), there was no significant correlation of fibrinogen and neutrophil levels with smoking status on COPD subjects (p> 0.05), Fibrinogen levels was significantly higher in exacerbation COPD than stable (p <0.001) but not with neutrophil, there was no significant correlation between smoking status and amount of cigarettes with  COPD severity(p> 0,05), there was significant correlation between fibrinogen levels with COPD severity (p <0.001) but not with neutrophils. Conclusion of this study is there was a correlation between fibrinogen with COPD incidence and severity.  However, neutrophils levels associated with COPD incidence.


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