The Importance of Prenatal Stress on the Development of ADHD in Children Literature Review 2019
Keywords:
Prenatal stress, Attention deficit hyperactivity disorder (ADHD), Vitamin D, Prenatal testosterone, Etiological factorsAbstract
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects children and often persists into adulthood. Research suggests that there is a link between maternal stress levels and the development of this condition. According to the Centers for Disease Control and Prevention (CDC), 6.1 million children living in the United States in 2016 had received a diagnosis of ADHD. The symptoms of ADHD can vary from person to person, but they typically include difficulties with concentrating, paying attention, and controlling impulses.It is not clear what causes ADHD, but scientists believe that genetics, certain environmental factors, and brain changes may play a role in its development. Researchers have also investigated the role of nutrients, such as vitamin D and hormone, such as prenatal testosterone. In this article, wewill reviewed the latest literature assessing the relationship between prenatal exposure to psychosocial stress during pregnancy and to the risk of developing behavioral problems related to attention deficit hyperactivity disorder (ADHD) in Childhood.
References
. Subcommittee on Attention-Deficit/Hyperactivity D, Steering Committee on Quality I, Management, Wolraich M, Brown L, Brown RT, DuPaul G, Earls M, Feldman HM, Ganiats TG, et al. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 2011;128(5):1007–22. doi: 10.1542/peds.2011-2654.
. Fayyad, J. et al. The descriptive epidemiology of DSM-IV Adult ADHD in the World Health Organization World Mental Health Surveys.ADHD Atten.Deficit Hyperact.Disord., https://doi.org/10.1007/s12402-016-0208-3 (2016)
. Swanson J, Arnold LE, Kraemer H, Hechtman L, Molina B, HinshawS, Vitiello B, Jensen P, Steinhoff K, Lerner M. Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of Children with ADHD (MTA) Part II: Supporting details. J AttenDisord 2008;12(1): 15–43.
. ATTENTION-DEFICIT SO. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 2011: peds. 2011–654.
. Klein RG, Mannuzza S, Olazagasti MAR, Roizen E, Hutchison JA, Lashua EC, Castellanos FX. Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiat 2012;69(12):1295–303.
. Dias TG, Kieling C, Graeff-Martins AS, Moriyama TS, Rohde LA, Polanczyk GV. Developments and challenges in the diagnosis and treatment of ADHD. Braz J Psychiatr. 2013;35Suppl 1:S40-50.
. Rohde, Buitelaar, Gerlach and Faraone, World Federation of ADHD. 2019
. Biederman J. Attention-deficit/hyperactivity disorder: a selective overview. Biol Psychiatry 2005;57(11):1215–20.
. Schneck-Gustaffson K, DeCola PR, Pfaff DW, Pisetsky DS (eds): Handbook of Cllinical Gender Medicine. Basel, Karger, 2012, pp 37-51 ,,Fetal Programming’’
. Barker DJ. The developmental origins of adult disease. European Journal of Epidemiology 2003;18(8):733-6.
. Van den Bergh BRH, van den Heuvel MI, Lahti M, Braeken M, de Rooij SR, Entringer S, Hoyer D, Roseboom T, Räikkönen K, King S, Schwab M. Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy. . 2017. doi: 10.1016/j.neubiorev.2017.07.003. [Epub ahead of print] Neuroscience and biobehavioral reviews
. Monk C, Lugo-Candelas C, Trumpff C. Prenatal developmental origins of future psychopathology: mechanisms and pathways. . 2019. doi:10.1146/annurev-clinpsy-050718-095539. [Epub ahead of print] Annual Review of Clinical Psychology
. O'Donnell KJ, Glover V, Barker ED, O'Connor TG.The persisting effect of maternal mood in pregnancy on childhood psychopathology. Developmental Psychopathology. 2014;26(2):393-403.
. Bergman K, Sarkar P, Glover V, O'Connor TG Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy. Journal of the American Academy of Child and Adolescent Psychiatry. 2007;46(11):1454-1463.
. Buss C, Davis EP, Muftuler LT, Head K, Sandman CA. High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psychoneuroendocrinology. 2010;35(1):141-53.
. Mennes M, Van den Bergh B, Lagae L, Stiers P. Developmental brain alterations in 17 year old boys are related to antenatal maternal anxiety. Clinical Neurophysiology. 2009;120(6):1116-1122.
. Moog NK, Entringer S, Rasmussen JM, Styner M, Gilmore JH, Kathmann N, Heim CM, Wadhwa PD, Buss C. Intergenerational effect of maternal exposure to childhood maltreatment on newborn brain anatomy. Biological Psychiatry. 2018;83(2):120-127.
. Capron LE, Glover V, Pearson RM, Evans J, O'Connor TG, Stein A, Murphy SE, Ramchandani PG. Associations of maternal and paternal antenatal mood with offspring anxiety disorder at age 18 years. Journal of Affective Disorders. 2015;187:20-26.
. O'Donnell KJ, Glover V, Lahti J, Lahti M, Edgar RD, Räikkönen K, O'Connor TG. Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD. PLoS One. 2017;12(6):e0177506.
. Yehuda R, Engel SM, Brand SR, Seckl J, Marcus SM, Berkowitz GS. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. 2005;90(7):4115- 4118. Journal of Clinical Endocrinology and Metabolism.
. Khashan AS, Abel KM, McNamee R, Pedersen MG, Webb RT, Baker PN, Kenny LC, Mortensen PB Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Archives of General Psychiatry. 2008;65(2):146-152.
. Vivette Glover, MA, PhD, DSc . The Effects of Prenatal Stress on Child Behavioural and Cognitive Outcomes Start at the Beginning. Institute of Reproductive and Developmental Biology, Imperial College London, United Kingdom.Encyclopedia on Early Childhood Development. April 2019, Rev. ed.
. Scassellati C, Bonvicini C, Faraone SV, Gennarelli M. Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. J Am Acad Child Adolesc Psychiatry. 2012;51(10):1003-1019.e20.
. Franz AP, Bolat GU, Bolat H, Matijasevich A, Santos IS, Silveira RC, et al. Attention-deficit/hyperactivity disorder and very preterm/very low birth weight: a meta-analysis. Pediatrics. 2018;141(1). pii: e20171645.
. Langley K, Rice F, van den Bree MB, Thapar A. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review. Minerva Pediatr. 2005;57(6):359-71.
. Adeyemo BO, Biederman J, Zafonte R, Kagan E, Spencer TJ, Uchida M, et al. Mild traumatic brain injury and ADHD: a systematic review of the literature and meta-analysis. J AttenDisord. 2014;18(7):576-84.
. Stevens SE, Kumsta R, Kreppner JM, Brookes KJ, Rutter M, Sonuga-Barke EJ. Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(6):753-61.
. Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002;288(6):728-37.
. Dong T, Hu W, Zhou X, Lin H, Lan L, Hang B, et al. Prenatal exposure to maternal smoking during pregnancy and attention-deficit/hyperactivity disorder in offspring: a meta-analysis. ReprodToxicol. 2018;76:63-70.
. Yoshimasu K, Kiyohara C, Takemura S, Nakai K. A meta-analysis of the evidence on the impact of prenatal and early infancy exposures to mercury on autism and attention deficit/hyperactivity disorder in the childhood.Neurotoxicology. 2014;44:121-31.
. Goodlad JK, Marcus DK, Fulton JJ. Lead and attention-deficit/hyperactivity disorder (ADHD) symptoms: a meta-analysis. ClinPsychol Rev. 2013;33(3):417-25.
. Khoshbakht Y, Bidaki R, Salehi-Abargouei A. Vitamin D status and attention deficit hyperactivity disorder: a systematic review and meta-analysis of observational studies. AdvNutr. 2018;9(1):9-20.
. Wolraich ML, Wilson DB, White JW. The effect of sugar on behavior or cognition in children.A meta-analysis.JAMA. 1995;274(20):1617-21.
. Thompson W, Russell G, Baragwanath G, Matthews J, Vaidya B, Thompson-Coon J. Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis. ClinEndocrinol (Oxf). 2018;88(4):575-584.
. Lundahl A, Kidwell KM, Van Dyk TR, Nelson TD. A meta-analysis of the effect of experimental sleep restriction on youth's attention and hyperactivity.DevNeuropsychol. 2015;40(3):104-21.
. Curran EA, O'Neill SM, Cryan JF, Kenny LC, Dinan TG, Khashan AS, et al. Research review: birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. J Child Psychol Psychiatry. 2015;56(5):500-8.
. Hoffmann MS, Polanczyk GV, Kieling C, Dos Santos IP, Willcutt EG, Rohde LA, et al. Attention-deficit/ hyperactivity disorder and solar irradiance: a cloudy perspective. Biol Psychiatry. 2014;76(8):e19-20.
. HawkeyE,Nigg JT. Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials.ClinPsychol Rev 2014;34(6):496–505. doi: 10.1016/j.cpr.2014.05.005.
. Rucklidge JJ, Frampton CM, Gorman B, Boggis A. Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: double-blind randomised placebo-controlled trial. Br J Psychiatry 2014;204:306–15. doi: 10.1192/bjp.bp.113.132126.
. Nigg JT, Lewis K, Edinger T, Falk M. Meta-analysis of attentiondeficit/ hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry 2012;51(1):86–97. e8.
. HeilskovRytter MJ, Andersen LBB, Houmann T, Bilenberg N, Hvolby A, Molgaard C, Michaelsen KF, Lauritzen L. Diet in the treatment of ADHD in children—a systematic review of the literature. Nord J Psychiatry 2015;69(1):1–18.
. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. J ChemNeuroanat 2005;29(1):21–30.
. Cui X, Pertile R, Liu P, Eyles D. Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience 2015;304:90–100.
. Patrick RP, Ames BN. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. FASEB J 2015;29(6):2207–22. doi: 10.1096/fj.14-268342.
. Celık G, Ta，s D, Tahıro˘glu A, Avci A, Yuksel B, Cam P. Vitamin D deficiency in obsessive-compulsive disorder patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: a case control study.NoroPsikiyatrArs 2016;53(1):31–4. doi: 10.5152/npa.2015.8763.
. Sharif MR, Madani M, Tabatabaei F, Tabatabaee Z. The relationship between serum vitamin D level and attention deficit hyperactivity disorder. Iran J Child Neurol 2015;9(4):48–53.
. Kamal M, Bener A, Ehlayel MS. Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? AttenDeficHyperactDisord 2014;6(2):73–8. doi: 10.1007/s12402-014-0130-5.
. Gustafsson P, Rylander L, Lindh CH, Jonsson BAG, Ode A, Olofsson P, Ivarsson SA, Rignell-Hydbom A, Haglund N, Kallen K. Vitamin D status at birth and future risk of attention deficit/hyperactivity disorder (ADHD). PloS One 2015;10(10). doi: 10.1371/journal.pone.0140164.
. Shang-Guan LL, Zhao YR. [Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder]. Zhongguo Dang Dai ErKeZaZhi 2015;17(8):837–40.
. Goksugur SB, Tufan AE, Semiz M, Gunes C, Bekdas M, Tosun M, Demircioglu F. Vitamin D status in children with attentiondeficit- hyperactivity disorder. PediatrInt 2014;56(4):515–9. doi: 10.1111/ped.12286.
. Bener A, Kamal M. Predict attention deficit hyperactivity disorder? Evidence-based medicine. Glob J Health Sci 2014;6(2):47–57. doi: 10.5539/gjhs.v6n2p47.
. Morales E, Julvez J, Torrent M, Ballester F, Rodriguez-Bernal CL, Andiarena A, Vegas O, Castilla AM, Rodriguez-Dehli C, Tardon A, et al. Vitamin D in pregnancy and attention deficit hyperactivity disorder-like symptoms in childhood. Epidemiology 2015;26(4):458– 65. doi: 10.1097/EDE.0000000000000292.
. Downloaded from https://academic.oup.com/advances/article-abstract/9/1/9/4848944 by guest on 30 July 2019
. Martel MM, Klump K, Nigg JT, Breedlove SM, Sisk CL. Potential hormonal mechanisms of attention-deficit/hyperactivity disorder and major depressive disorder: a new perspective. HormBehav. 2009;55(4):465–479.
. Davies W. Sex differences in attention deficit hyperactivity disorder: candidate genetic and endocrine mechanisms. Front Neuroendocrinol. 2014;35(3):331–346.
. Brunton PJ. Programming the brain and behaviour by early-life stress: a focus on neuroactive steroids.J Neuroendocrinol. 2015;27(6): 468–480.
. Hines M, Brook C, Conway GS: Androgen and psychosexual development: core gender identity, sexual orientation and recalled childhood gender role behavior in women and men with congenital adrenal hyperplasia (CAH). J Sex Res 2004;41:1-7
. Morris JA, Jordan CL, Breedlove SM. Sexual differentiation of the vertebrate nervous system. Nat Neurosci. 2004;7(10):1034–1039
. Baron –Cohen S, Lutchmaya S, Knickmeyer R: Prenatal Tesosterone in Mind . Cambridge, MIT Press, 2004.
. Talge NM, Neal C, Glover V: Antenatal Maternal stress and long-term effects on child neurodevelopment:how and why? J Child Psychol Psychiatry 2007; 48:245-261.
. Mahone EM. Why fewer females than males are diagnosed with attention-deficit-hyperactivity disorder: it might not be hormones. Dev Med Child Neurol. 2010;52(9):790–791.
. Lemiere J, Boets B, Danckaerts M. No association between the 2D:4D fetal testosterone marker and multidimensional attentional abilities in children with ADHD. Dev Med Child Neurol. 2010;52(9):e202–e208.
. Liu J, Portnoy J, Raine A. Association between a marker for prenatal testosterone exposure and externalizing behavior problems in children. DevPsychopathol. 2012;24(3):771–782.
. Lee S. S. Humphreys K. L. Flory K. Liu R. Glass K. ( 2011 ). Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: A meta-analytic review . Clinical Psychology Review , 31 , 328 – 341 . doi:10.1016/j.cpr.2011.01.006 [doi]
. Fuemmeler B. F. Kollins S. H. McClernon F. J. ( 2007 ). Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood . Journal of Pediatric Psychology , 32 , 1203 – 1213 . doi:jsm051 [pii]
. Molina B. S. Pelham W. E. Jr. ( 2003 ). Childhood predictors of adolescent substance use in a longitudinal study of children with ADHD . Journal of Abnormal Psychology , 112 , 497 – 507 .
. Spencer T. J. Faraone S. V. Tarko L. McDermott K. Biederman J. ( 2014 ). Attention-deficit/hyperactivity disorder and adverse health outcomes in adults . The Journal of Nervous and Mental Disease , 202 , 725 – 731 .
. Bleck J. DeBate R. D. ( 2013 ). Exploring the co-morbidity of attention-deficit/hyperactivity disorder with eating disorders and disordered eating behaviors in a nationally representative community-based sample . Eating Behaviors , 14 , 390 – 393 . doi:10.1016/j.eatbeh.2013.05.009 [doi]
. Brown L. K. Hadley W. Stewart A. Lescano C. Whiteley L. Donenberg G. DiClemente R. ( 2010 ). Psychiatric disorders and sexual risk among adolescents in mental health treatment . Journal of Consulting and Clinical Psychology , 78 , 590 – 597 .
. Flory K. Molina B. S. Pelham W. E. Jr. Gnagy E. Smith B. ( 2006 ). Childhood ADHD predicts risky sexual behavior in young adulthood . Journal of Clinical Child and Adolescent Psychology , 35 , 571 – 577 . doi:10.1207/s15374424jccp3504_8 [doi]
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