In Vitro Comparative Cardioprotective Activity of Methanol Extract of Caesalpinia Digyna (Rottl.) Stems and Senna Sophera (L.) Roxb. Stems

Authors

  • Nazim Uddin Emon Department of Pharmacy, International Islamic University Chittagong, Bangladesh, Phone:+88-01648094589
  • Israt Jahan Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Sajib Rudra Department of Botany, Chittagong University, Chittagong, Bangladesh
  • Dr. Mohammed Aktar Sayeed Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Md. Mohotasin Hossain Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Md. Solaman Uddin Sawon Department of Pharmacy, International Islamic University Chittagong, Bangladesh
  • Mohammad Nazmul Islam Department of Pharmacy, International Islamic University Chittagong, Bangladesh

Keywords:

Clot lysis, Streptokinase, Caesalpinia Digyna, Senna sophera, Human blood

Abstract

The present study was meant to explore the thrombolytic action of methanol extract of Senna sophera stems (MESS) and Caesalpinia digyna stems (MECD) alongside streptokinase as positive control and saline water as negative control. In the In vitro thrombolytic model, the MESS stems and MECD stems has been indicated 32.79±4.51% and 9.19±0.80% clot lysis individually. Between two extracts, MESS stems. has been demonstrated the noteworthy percent of clot lysis (32.79±4.51%) with reference to streptokinase (66.09±2.37%). From our investigation it has been uncovered that between the plants, MESS stems uncovered moderate thrombolytic action. In this way, steps ought to be taken to search in vitro clot dissolving potential and to isolate dynamic segments of MESS Stem for clot lysis are proposed to found. After found, MESS Stem could be recommended as a clot lysis agent in the treatment of patients experiencing disease related with blood clot (Myocardial Infraction, Hypertension, atherosclerosis, Peripheral artery sickness, heart attack and so forth)”.

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Published

2019-12-01

How to Cite

Emon, N. U., Jahan, I. ., Rudra, S. ., Sayeed, D. M. A. ., Hossain, M. M. ., Sawon, M. S. U. ., & Islam, M. N. . (2019). In Vitro Comparative Cardioprotective Activity of Methanol Extract of Caesalpinia Digyna (Rottl.) Stems and Senna Sophera (L.) Roxb. Stems. International Journal of Sciences: Basic and Applied Research (IJSBAR), 48(7), 189–196. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/10493

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