In Vitro Comparative Cardioprotective Activity of Methanol Extract of Caesalpinia Digyna (Rottl.) Stems and Senna Sophera (L.) Roxb. Stems
Keywords:
Clot lysis, Streptokinase, Caesalpinia Digyna, Senna sophera, Human bloodAbstract
The present study was meant to explore the thrombolytic action of methanol extract of Senna sophera stems (MESS) and Caesalpinia digyna stems (MECD) alongside streptokinase as positive control and saline water as negative control. In the In vitro thrombolytic model, the MESS stems and MECD stems has been indicated 32.79±4.51% and 9.19±0.80% clot lysis individually. Between two extracts, MESS stems. has been demonstrated the noteworthy percent of clot lysis (32.79±4.51%) with reference to streptokinase (66.09±2.37%). From our investigation it has been uncovered that between the plants, MESS stems uncovered moderate thrombolytic action. In this way, steps ought to be taken to search in vitro clot dissolving potential and to isolate dynamic segments of MESS Stem for clot lysis are proposed to found. After found, MESS Stem could be recommended as a clot lysis agent in the treatment of patients experiencing disease related with blood clot (Myocardial Infraction, Hypertension, atherosclerosis, Peripheral artery sickness, heart attack and so forth)”.
References
. Cambien, F., et al., Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature, 1992. 359(6396): p. 641-644.
. Ramjan, A., et al., Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds. Avicenna journal of phytomedicine, 2014. 4(6): p. 430.
. Laurence, D., Ethics and law in clinical pharmacology. British journal of clinical pharmacology, 1989. 27(6): p. 715.
. Mucklow, J., Thrombolytic treatment. Streptokinase is more economical than alteplase. BMJ: British Medical Journal, 1995. 311(7018): p. 1506.
. Goldhaber, S.Z., Thrombolysis in pulmonary embolism: a debatable indication. Thromb Haemost, 2001. 86(1): p. 444-51.
. Ghosh, A., Herbal folk remedies of Bankura and Medinipur districts, West Bengal. 2003.
. Demrow, H.S., P.R. Slane, and J.D. Folts, Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation, 1995. 91(4): p. 1182-1188.
. Prasad, S., et al., Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis. BMC Complement Altern Med, 2007. 7: p. 36.
. Prasad, S., et al., Development of an in vitro model to study clot lysis activity of thrombolytic drugs. Thrombosis Journal, 2006. 4(1): p. 14.
. Bazzano, L.A., et al., Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. The American journal of clinical nutrition, 2002. 76(1): p. 93-99.
. Wardlaw, J., et al., Thrombolysis for acute ischemic stroke. Stroke, 2004. 35(12): p. 2914-2915.
. Gillman, M.W., et al., Protective effect of fruits and vegetables on development of stroke in men. Jama, 1995. 273(14): p. 1113-7.
. Zaman, R., et al., In vitro clot lysis activity of different extracts of mangifera sylvatica roxb. Leaves. Research Journal of Medicinal Plant, 2015. 9(3): p. 135-140.
. Gallus, A., 7 Thrombolytic therapy for venous thrombosis and pulmonary embolism. Baillière's clinical haematology, 1998. 11(3): p. 663-673.
. Prentice, C., Platelets and atherosclerosis. European heart journal supplements, 1999. 1(A): p. A3-A7.
. Banerjee, A., Y. Chisti, and U.C. Banerjee, Streptokinase--a clinically useful thrombolytic agent. Biotechnol Adv, 2004. 22(4): p. 287-307.
. Krishnaraju, A.V., et al., Biological screening of medicinal plants collected from Eastern Ghats of India using Artemia salina (brine shrimp test). Int. J. Appl. Sci. Eng, 2006. 4(2): p. 115-125.
. Prasad, S., et al., Effect of Fagonia arabica (Dhamasa) on in vitro thrombolysis. BMC Complementary and Alternative Medicine, 2007. 7(1): p. 36.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 International Journal of Sciences: Basic and Applied Research (IJSBAR)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors who submit papers with this journal agree to the following terms.