Insulin-Like Growth Factor-I (IGF-I) in Reproductive System of Female - A Review
IGF-I in Female Reproductive System
Keywords:
Insulin-like Growth Factor–I, endocrine, paracrine, autocrine, female reproductive systemAbstract
Insulin-like Growth Factor-I is a peptide with a molecular weight of 7649 Da. The IGF system is a complex molecule that can act autocrine, paracrine and endocrine which can be produced in the uterus, oviduct, ovaries, hypothalamus, and liver. Basically, IGF consists of six IGF-binding proteins (IGFBP 1 to 6) and two growth factors are IGF-I and IGF-II, two cell surface receptors (IGF-IR and IGF mannose-6-phosphate receptor (M-6-PR)) and nine related IGFBP proteins (IGFBP-rPS). IGFs are involved in cell proliferation, growth, differentiation and survival of cells as well as in metabolic regulation protein, glucose, and fat. Unlike insulin, the circulation of IGFs in complex plasma with a group of IGF specific binding proteins (IGFBPs). In the circulatory system more than 99% of IGFs are bound and means less than 1% in free. IGF-I plays a role in the female reproductive system, especially in the ovaries to stimulate development and growth of follicles (preantral follicles to antral follicles), stimulate the onset of puberty, maintain estrous cycles until can get pregnant, and during the postpartum period.
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