Significance of Serum Prostate Specific Antigen with Histopathological Grading in Men with Prostate adenocarcinoma at Makassar, Indonesia

Abstract

Prostate adenocarcinoma is the second most common malignancy in men after lung cancer worldwide. In Makassar, South Sulawesi, prostate adenocarcinoma cases increased significantly, from 2017, 2018 and 2019 respectively, the cases reached 31, 43 and 51 cases. Although not specific, Prostate Specific Antigen (PSA) is the first-line test in the screening of prostate adenocarcinoma. Gleason grading is one of the most powerful predictors of biological behavior and when combined PSA with Gleason score and clinical stage. It improves the prediction of the pathological stage for prostate carcinoma. The aim of this study was to determine the association between serum PSA concentration and the new (2016 modified) This was a retrospective study of the correlation between age of patients, serum PSA and grade group of Gleason score of patients diagnosed as Prostate Adenocarcinoma with HE staining at Anatomical Pathology Laboratory, Faculty of Medicine, Hasanuddin University. The age of patients and  the serum PSA values  were retrieved from  laboratory files. Histological slides of appropriate cases were reviewed to confirm the Gleason score and group grade. There were 27 cases fulfilled criteria, from September 2020 to November 2021. The data obtained were subjected to statistical analysis to look for associations and correlations serum PSA and group grade of prostate adenocarcinoma. This study showed that there was a significant correlation between serum PSA level with histopathological grading based on Gleason score of prostate adenocarcinoma (p<0,05).