Clinicopathological Profile of Colorectal Cancer Patients in Anatomical Pathology Department of Hasanuddin University Makassar
Keywords:colorectal adenocarcinoma, clinicopathological profile, makassar
Colorectal cancer (CRC) is the third most common cancer in men, the second in women, and it’s the second for leading cause of cancer death worldwide, with more than 1.2 million new cancer cases and 608,700 deaths. The World Health Organization (WHO) in 2018, explained that globally there were 1.80 million new cases of colorectal cancer diagnosed and 862,000 patients died of colorectal cancer. This study aims to define the epidemiological and clinicopathological characteristics of CRC with metastasize in Makassar. Retrospective study was performed used cross-sectional design included all patients diagnosed with colorectal adenocarcinoma with metastasize at Anatomical Pathology Laboratory Dr. Wahidin Sudirohusodo, Faculty of Medicine Hasanuddin University and Makassar Pathology Diagnostic Center, from January 2016 to December 2021. A total of 60 patients were included in this study, 45% were females and 55% were males. Samples with the age category <50 years were 13 samples (21.7%) and the age category > 50 years were 47 samples (78.3%). Based on the location of the tumor, the location of tumor in the right colon were 24 samples (40.0%), in the left colon were 14 samples (23.3%), and in the rectum were 22 (36.7%) samples. The low-grade colorectal adenocarcinoma group were consisted of 31 samples (51.7%) and 29 samples (48.3%) of the high-grade. Samples with positive lymphovascular invasion were 17 samples (51.7%) and 43 samples (71.7%) were negative.The depth of invasion were 28 samples (46.7%) at muscularis externa and 32 samples (53.3%) at serosa. Colorectal adenocarcinoma is more frequent at the age more than 50 years old and right colon is the most affected sub site. The mean age at diagnosis was 57.2 years with male predominance. Most patients had low grade tumor, no lymphovascular invasion findings at microscopic and the depth of invasion reach the serosa. Lymph nodes is the most common metastatic site.
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