Clinicopathological Profile of Colorectal Cancer Patients in Anatomical Pathology Department of Hasanuddin University Makassar

Authors

  • Lenda Olivia Gaghana Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia
  • Upik Anderiani Miskad Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia
  • Muhammad Husni Cangara Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia
  • Andi Alfian Zainuddin Department of Public Health, Hasanuddin University, Indonesia
  • Mardiati Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia
  • Gunawan Arsyadi Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia
  • Syarifuddin Wahid Department of Pathology, Faculty of Medicine, Hasanuddin University, Indonesia

Keywords:

colorectal adenocarcinoma, clinicopathological profile, makassar

Abstract

Colorectal cancer (CRC) is the third most common cancer in men, the second in women, and it’s the second for leading cause of cancer death worldwide, with more than 1.2 million new cancer cases and 608,700 deaths. The World Health Organization (WHO) in 2018, explained that globally there were 1.80 million new cases of colorectal cancer diagnosed and 862,000 patients died of colorectal cancer. This study aims to define the epidemiological and clinicopathological characteristics of CRC with metastasize in Makassar. Retrospective study was performed used cross-sectional design included all patients diagnosed with colorectal adenocarcinoma with metastasize at Anatomical Pathology Laboratory Dr. Wahidin Sudirohusodo, Faculty of Medicine Hasanuddin University and Makassar Pathology Diagnostic Center, from January 2016 to December 2021. A total of 60 patients were included in this study, 45% were females and 55% were males. Samples with the age category <50 years were 13 samples (21.7%) and the age category > 50 years were 47 samples (78.3%). Based on the location of the tumor, the location of tumor in the right colon were 24 samples (40.0%), in the left colon were 14 samples (23.3%), and in the rectum were 22 (36.7%) samples. The low-grade colorectal adenocarcinoma group were consisted of 31 samples (51.7%) and 29 samples (48.3%) of the high-grade. Samples with positive lymphovascular invasion were 17 samples (51.7%) and 43 samples (71.7%) were negative.The depth of invasion were 28 samples (46.7%) at muscularis externa and 32 samples (53.3%) at serosa.   Colorectal adenocarcinoma is more frequent at the age more than 50 years old and right colon is the most affected sub site. The mean age at diagnosis was 57.2 years with male predominance. Most patients had low grade tumor, no lymphovascular invasion findings at microscopic and the depth of invasion reach the serosa. Lymph nodes is the most common metastatic site.

References

. Effendi-YS, R., & Rey, I. (2018. Cancer Stem Cells and Signaling Pathways in Colorectal Cancer. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 19(1), 37. https://doi.org/10.24871/191201837-41

. Liao, M. Y., Kuo, M. Y. P., Lu, T. Y., Wang, Y. P., & Wu, H. C. (2015). Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer. International Journal of Oncology, 46(4), 1788–1800. https://doi.org/10.3892/ijo.2015.2876

. Ahmed, M. (2020). Colon Cancer: A Clinician’s Perspective in 2019. Gastroenterology Research, 13(1), 1–10. https://doi.org/10.14740/gr1239

. Kementerian Kesehatan Republik Indonesia. (2018). PEDOMAN NASIONAL PELAYANAN KEDOKTERAN TATA LAKSANA KANKER KOLOREKTAL. KEPUTUSAN MENTERI KESEHATAN REPUBLIK INDONESIA.

. World Health Organization. (2020). Cancer Insiden in Indonesia. International Agency for Research on Cancer, 858, 1–2.

. Li, C. J., Zhang, X., & Fan, G. W. (2014). Updates in colorectal cancer stem cell research. Journal of Cancer Research and Therapeutics, 10(8), C233–C239. https://doi.org/10.4103/0973-1482.151449

. Kumar, Vinay., Abbas, Abul K., Aster, J. C. (2021). Neoplasia. In Robbins & Cotran Pathologic Basis of Disease (Tenth Edit, pp. 267–336). Elsevier.

. ACS. (2020b). Colorectal Cancer Facts and Figures 2020-2022. American Cancer Society, 66(11), 1–41. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/colorectal-cancer-facts-and-figures/colorectal-cancer-facts-and-figures-2020-2022.pdf

. Haggar, F. A., & Boushey, R. P. (2009). Colorectal cancer epidemiology: Incidence, mortality, survival, and risk factors. Clinics in Colon and Rectal Surgery, 22(4), 191–197. https://doi.org/10.1055/s-0029-1242458

. Siegel, R. L., Jakubowski, C. D., Fedewa, S. A., & Davis, A. (2022). Colorectal Cancer in the Young?: Epidemiology , Prevention , Management. 75–88.

. Vuik, F. E. R., Nieuwenburg, S. A. V., Bardou, M., Lansdorp-Vogelaar, I., Dinis-Ribeiro, M., Bento, M. J., Zadnik, V., Pellisé, M., Esteban, L., Kaminski, M. F., Suchanek, S., Ngo, O., Májek, O., Leja, M., Kuipers, E. J., & Spaander, M. C. W. (2019). Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut, 1820–1826. https://doi.org/10.1136/gutjnl-2018-317592

. Abancens, M., Bustos, V., Harvey, H., McBryan, J., & Harvey, B. J. (2020). Sexual Dimorphism in Colon Cancer. Frontiers in Oncology, 10(December), 1–27. https://doi.org/10.3389/fonc.2020.607909

. Majek, O., Gondos, A., Jansen, L., Emrich, K., Holleczek, B., Katalinic, A., Nennecke, A., Eberle, A., & Brenner, H. (2013). Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany. PLoS ONE, 8(7), 1–7. https://doi.org/10.1371/journal.pone.0068077

. Nagtegaal, I., Arends, MJ; Odze, R., & Lam, A. (2019). Tumours of the colon and rectum. In WHO Classification of Tumours Digestive System Tumours (5th ed.). World Health Organization.

. Mangone, L., Pinto, C., Mancuso, P., Ottone, M., Bisceglia, I., Chiaranda, G., Michiara, M., Vicentini, M., Carrozzi, G., Ferretti, S., Falcini, F., Hassan, C., & Rossi, P. G. (2021). Colon cancer survival differs from right side to left side and lymph node harvest number matter. BMC Public Health, 21(1), 1–10. https://doi.org/10.1186/s12889-021-10746-4

. Baran, B., Mert Ozupek, N., Yerli Tetik, N., Acar, E., Bekcioglu, O., & Baskin, Y. (2018). Difference Between Left-Sided and Right-Sided Colorectal Cancer: A Focused Review of Literature. Gastroenterology Research, 11(4), 264–273. https://doi.org/10.14740/gr1062w

. Jiang HH, Zhang ZY, Wang XY, Tang X, Liu HL, Wang AL, Li HG, Tang EJ, Lin MB. Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations. World J Gastroenterol. 2019 May 28;25(20):2489-2502. doi: 10.3748/wjg.v25.i20.2489. PMID: 31171892; PMCID: PMC6543237.

. Ichimasa K, Kudo SE, Miyachi H, Kouyama Y, Hayashi T, Wakamura K, Hisayuki T, Kudo T, Misawa M, Mori Y, Matsudaira S, Hidaka E, Hamatani S, Ishida F. Comparative clinicopathological characteristics of colon and rectal T1 carcinoma. Oncol Lett. 2017 Feb;13(2):805-810. doi: 10.3892/ol.2016.5464. Epub 2016 Dec 6. PMID: 28356962; PMCID: PMC5351395.

. Maeyama Y, Mitsuyama K, Noda T, Nagata S, Nagata T, Yoshioka S, Yoshida H, Mukasa M, Sumie H, Kawano H, Akiba J, Araki Y, Kakuma T, Tsuruta O, Torimura T. Prediction of colorectal tumor grade and invasion depth through narrow-band imaging scoring. World J Gastroenterol. 2018 Nov 14;24(42):4809-4820. doi: 10.3748/wjg.v24.i42.4809. PMID: 30479467; PMCID: PMC6235797.

Downloads

Published

2022-09-17

How to Cite

Lenda Olivia Gaghana, Upik Anderiani Miskad, Muhammad Husni Cangara, Andi Alfian Zainuddin, Mardiati, Gunawan Arsyadi, & Syarifuddin Wahid. (2022). Clinicopathological Profile of Colorectal Cancer Patients in Anatomical Pathology Department of Hasanuddin University Makassar. International Journal of Sciences: Basic and Applied Research (IJSBAR), 64(1), 20–27. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14532

Issue

Vol. 64 No. 1 (2022)

Section

Articles

License

Copyright (c) 2022 International Journal of Sciences: Basic and Applied Research (IJSBAR)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who submit papers with this journal agree to the following terms.