Clinicopathological Characteristics of Placenta Samples of Preeclampsia
Keywords:
placenta, preeclampsia, Clinicopathological characteristicsAbstract
Preeclampsia is a systemic syndrome in pregnancy that is characterized by decreased organ perfusion due to endothelial dysfunction and systemic inflammation. It caused by many proposed etiologies and multifactorial factors behind it, thus preeclampsia is known as the disease of theory. Preeclampsia can be divided into 2 categories based on the clinical presentation, which are: preeclampsia and severe preeclampsia. The aim of this study is to determine the clinicopathological characteristics of preeclampsia patients. A descriptive study using 56 samples of placenta from preeclampsia patients was conducted, and the following clinical characteristics were presented: age, gestational age, gravida, and hypertension history. Preeclampsia was found in 51.8% of the samples (29) and severe preeclampsia was found in 48.2% of the samples (27). Most samples (69.6%) had an age range of 20-35 years, 73.2% (41 samples) had 2-5 times of pregnancy (gravida), 76.8% (43 samples) had 37-42 weeks of pregnancy, and most samples (73.2%) had no hypertension history. The histopathological found calcification and syncytial knots in villi chorialis.
References
A. Wang, S. Rana, and S. A. Karumanchi, “Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis,” vol. 24, p. 12, 2009.
PNPK POGI, Diagnosa dan Tatalaksana Pre-Eklamsia, Pedoman Nasional Pelayanan Kedokteran (PNPK). 2016.
A. M. Gashi, “The Woman with Severe Preeclampsia Who Died from Postpartum Complications,” p. 6, 2016.
K. Ojha, S. Rawal, and A. Jha, “Placental Pathology in Severe Pre-eclampsia and Eclampsia,” Nep. Med. J., vol. 1, no. 1, pp. 32–35, Jun. 2018, doi: 10.3126/nmj.v1i1.20397.
S. Shah and A. Gupta, “Hypertensive Disorders of Pregnancy,” Cardiology Clinics, vol. 37, no. 3, Art. no. 3, Aug. 2019, doi: 10.1016/j.ccl.2019.04.008.
L. R. Leffert, C. R. Clancy, B. T. Bateman, A. S. Bryant, and E. V. Kuklina, “Hypertensive Disorders and Pregnancy-Related Stroke: Frequency, Trends, Risk Factors, and Outcomes,” Obstetrics & Gynecology, vol. 125, no. 1, pp. 124–131, Jan. 2015, doi: 10.1097/AOG.0000000000000590.
K. Duckitt and D. Harrington, “Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies,” BMJ, vol. 330, no. 7491, Art. no. 7491, Mar. 2005, doi: 10.1136/bmj.38380.674340.E0.
B. M. Sibai, “Diagnosis, Prevention, and Management of Eclampsia:,” Obstetrics & Gynecology, vol. 105, no. 2, Art. no. 2, Feb. 2005, doi: 10.1097/01.AOG.0000152351.13671.99.
G. A. Tessema, A. Tekeste, and T. A. Ayele, “Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: a hospital-based study,” BMC Pregnancy Childbirth, vol. 15, no. 1, p. 73, Dec. 2015, doi: 10.1186/s12884-015-0502-7.
N. T. F. Vincent, I. M. Darmayasa, and A. Suardika, “Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017,” Intisari Sains Medis, vol. 9, no. 2, May 2018, doi: 10.15562/ism.v9i2.162.
C. V. Ananth and O. Basso, “Impact of Pregnancy-induced Hypertension on Stillbirth and Neonatal Mortality,” Epidemiology, vol. 21, no. 1, pp. 118–123, Jan. 2010, doi: 10.1097/EDE.0b013e3181c297af.
R. Lamminpää, K. Vehviläinen-Julkunen, M. Gissler, and S. Heinonen, “Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997–2008,” BMC Pregnancy Childbirth, vol. 12, no. 1, p. 47, Dec. 2012, doi: 10.1186/1471-2393-12-47.
D. Mostello, D. Kallogjeri, R. Tungsiripat, and T. Leet, “Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births,” American Journal of Obstetrics and Gynecology, vol. 199, no. 1, p. 55.e1-55.e7, Jul. 2008, doi: 10.1016/j.ajog.2007.11.058.
J. M. Catov, R. B. Ness, K. E. Kip, and J. Olsen, “Risk of early or severe preeclampsia related to pre-existing conditions,” International Journal of Epidemiology, vol. 36, no. 2, pp. 412–419, Apr. 2007, doi: 10.1093/ije/dyl271.
G. M. Egeland, K. Klungsøyr, N. Øyen, G. S. Tell, Ø. Næss, and R. Skjærven, “Preconception Cardiovascular Risk Factor Differences Between Gestational Hypertension and Preeclampsia: Cohort Norway Study,” Hypertension, vol. 67, no. 6, pp. 1173–1180, Jun. 2016, doi: 10.1161/HYPERTENSIONAHA.116.07099.
P. C. F. M. Bezerra et al., “Family history of hypertension as an important risk factor for the development of severe preeclampsia,” Acta Obstet Gynecol Scand, vol. 89, no. 5, pp. 612–617, May 2010, doi: 10.3109/00016341003623720.
M. Kos and E. Matkovich, “Bcl-2 and Bax immunoreactivity in placentas from pregnancies complicated with intrauterine growth restriction and hypertension,” Period biol, vol. 116, no. 2, Art. no. 2, 2014.
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