Effect of Chronic Use of Recreational Drugs on the Sperm Count in Albino Mice

Authors

  • Sravonee Purkayastha
  • Rita Mahanta

Keywords:

AAS, Alcohol, Drug abuse, Nicotine, Recreational Drugs, Sperm count.

Abstract

Chronic use of various recreational drugs is leading to drug abuse which is increasingly developed in the modern society among the various populations throughout the world. The present study was conducted to investigate the impact of a few recreational drugs viz., anabolic androgenic steroids (AAS), alcohol and nicotine on male fertility status which was assessed by measuring sperm count in male albino mice. Semen samples were collected from normal, AAS-treated, alcohol-treated and nicotine-treated

References

Mosher WD, Pratt WF. Fecundity and infertility in the United States: incidence and trends. Fertil Steril 1991; 56: 192-193.

Chachamovich JR, Chachamovich E, Ezer H, Fleck MP, Knauth D, Passos EP. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynaecol 2010; 31(2): 101

Cui W (2010) Mother or nothing: the agony of infertility. Bull World Health Organ 88: 881

Yesilli C, Mungan G, Seckiner I, Akduman B, Acikgoz S, Altan K et al. Effect of varicocelectomy on sperm creatin kinase, HspA2 chaperone protein (creatine kinase-M type), LDH, LDH-X and lipid peroxidation product levels in infertile men with varicocele. Urology 2005; 66: 610-15.

Rowe T. Fertility and a woman's age. J Reprod Med 2006, 51: 157

Lekamge DN, Lane M, Gilchrist RB, Tremellen KP. Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve. J Assist Reprod Genet 2008, 25: 515

Desai N, Sharma R, Makker K, Sabanegh E, Agarwal A. Physiologic and pathologic levels of reactive oxygen species in neat semen of infertile men. Fertil Steril 2009, 92: 1626

Saalu LC. The incriminating role of reactive oxygen species in idiopathic male infertility: an evidence based evaluation. Pak J Biol Sci 2010; 13: 413

Fronczak CM, Kim ED, Barqawi AB. The insults of illicit drug use on male fertility. J Androl 2012; 33(4): 515-28.

Duchaine D. Underground Steroid Handbook II. 1989.

American Medical Association. Medical and nonmedical uses of anabolic steroids. Council on scientific affairs. JAMA 1990; 264: 2923-2927.

Terney R, McLain L. The use of anabolic steroids in high school students. Am J Dis Child 1990; 144:99-103.

Handelsman DJ, Grupta L. Prevalence and risk factors for anabolic-androgenic steroid abuse in Australian high school students. Int J Androl. 1997; 20: 159-164.

Korkia P, Stimson GV. Indications of prevalence, practice and effects of anabolic steroid use in Great Britain. Int J Sports Med 1997; 18: 557-562.

Kindlundh AM, Isacson DG, Berglund L, Nyberg F. Factors associated with adolescent use of doping agents: anabolic-androgenic steroids. Addiction 1999; 94 (4): 543-53.

NIDA Research Report - Steroid abuse and addiction: NIH Publication No. 00-3721. April, 2000.

Nilsson S, Baigi A, Marklund B, Fridlund B. Trends in the misuse of androgenic anabolic steroids among boys 16-17 years old in a primary health care area in Sweden. Scand J Prim Health Care 2001; 19: 181-182.

Tan RS, Scally MC. Anabolic steroid-induced hypogonadism: towards a unified hypothesis of anabolic steroid action. Med Hypotheses 2009; 72: 723

Takahashi M, Tatsugi Y, Kohno T. Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocr J 2004; 51: 425-434.

Kilshaw BH, Harkness RA, Hobson BM, Smith AW. The effects of large doses of the anabolic steroids, methandrostenolone, on an athlete. Clin Endocrinol 1975; 4: 537-541.

Schurmeyer T, Knuth UA, Belkien L, Nieschlag E. Reversible azoospermia induced by the anabolic steroid 19-nortestosterone. Lancet 1984; 1: 417-420.

Jarow JP, Lipshultz LI. Anabolic steroid-induced hypogonadotropic hypogonadism. Am J Sports Med 1990; 18: 429-431.

NIDA Research Monograph Series 102. Anabolic Steroid Abuse. Lin GC, Erinoff L Eds. National Institute on Drug Abuse, Rockvilee 1990.

Sader MA, Griffiths KA, McCredie RJ, Handelsman DJ, Celermajer DS. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 2001; 37(1): 224-230.

INCSR. Legislative Basis for the INCSR. The Department of State's Bureau for International Narcotics and Law Enforcement Affairs (INL) 2001.

Miller NS, Gold MS. Comorbid Cigarette and Alcohol Addiction: Epidemiology and Treatment 1998.

Emanuele MA, Emanuele NV. Alcohol's effects on male reproduction. Alcohol Health Res World 1998; 22: 195-218.

Moyer D. The Tobacco Reference Guide 2000.

INFOFAX. Cigarettes and Other Nicotine Products (13545). National Institute of Drug Abuse, 2001.

Acharjee BK, Mahanta R, Borkotoky A. Nandrolone Decanoate Enhances the Activities of Cholanthrene Induced Glutathione-s-Transferase in Liver Tissue of Albino Mice. Drug Metabolism Letters 2010; 4: 1-6

Purkayastha S, Mahanta R..Effect of nandrolone decanoate on serum fsh, lh and testosterone concentration in male albino mice. World Journal of Life Sciences and Medical Research 2012; 2(3): 123-7.

Attia Sabry M. The genotoxic and cytotoxic effects of nicotine in the mouse bone marrow. Mutation Research 2007; 632(1-2): 29-36.

Wennemuth G, Westenbroek RE, Xu T, Hille B, Babcock BF. CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization evoked entry of Ca2+ into mouse sperm. J Biol Chem 2000; 275: 21210

Rahman MM, Mandal BK, Chowdhury TR, Sengupta MK, Chowdhury UK, Lodh D et al. Arsenic groundwater contamination and sufferings of people in North 24-Parganas, one of the nine arsenic affected districts of West Bengal, India. J Environ Sci Health Part A Tox Hazard Subst Environ Eng. 2003; 38: 25-59.

Croxton FE. Elementary Statistics with application in medicine and biological science. Dover, New Delhi. 1953.

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Published

2014-03-31

How to Cite

Purkayastha, S., & Mahanta, R. (2014). Effect of Chronic Use of Recreational Drugs on the Sperm Count in Albino Mice. International Journal of Sciences: Basic and Applied Research (IJSBAR), 13(1), 466–474. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/1835

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