Valproic Acid Administration in Pregnant Rats Affects Litter Size, Birth Weight, and Postnatal Growth of the Offspring

Authors

  • Komariah Komariah Graduate Student of Physiology and Pharmacology Study Program, Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Darmaga, Bogor 16680, West Java, Indonesia, Department of Histology, Faculty of Dentistry, Trisakti University
  • Bambang Kiranadi Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Darmaga, Bogor 16680, West Java, Indonesia
  • Adi Winarto Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Darmaga, Bogor 16680, West Java, Indonesia
  • Wasmen Manalu Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Darmaga, Bogor 16680, West Java, Indonesia
  • Ekowati Handharyani Department of Clinic, Reproduction, and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Darmaga, Bogor 16680, West Java, Indonesia

Keywords:

Litter Size, Birth Weight, Postnatal Growth, Valproic Acid.

Abstract

An experiment was conducted to study the effects of valproic acid, a well-known teratogen compound during the process of organogenesis, on fetal survival, prenatal and postnatal growths of the offspring. Thirty pregnant female Sprague-Dawley rats were divided into 4 groups i.e., pregnant rats without valproic acid administration as a control and pregnant rats administered with 250 mg valproic acid on days 10, 13, 16 of pregnancy. Litter size at parturition and individual birth weight of the offspring were measured.

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Published

2017-06-03

How to Cite

Komariah, K., Kiranadi, B., Winarto, A., Manalu, W., & Handharyani, E. (2017). Valproic Acid Administration in Pregnant Rats Affects Litter Size, Birth Weight, and Postnatal Growth of the Offspring. International Journal of Sciences: Basic and Applied Research (IJSBAR), 33(3), 174–186. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/7352

Issue

Vol. 33 No. 3 (2017)

Section

Articles

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