The Effect of ACTH 4-10 ProGlyPro as Anti-inflammatory on Astrocyte Cell Repair in Spinal-Cord-Injured Mouse by Assessing Locomotor Function

Authors

  • Alfred Sutrisno Sim Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Ilhamjaya Patellongi Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Irawan Yusuf Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Suryani As'ad Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Syarifuddin Wahid Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Susi Aulina Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Peter Kabo Departement of Cardiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Dondin sajuthi Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural Institute, Bogor, Indonesia
  • Andi Asadul Islam Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Keywords:

ACTH 4-10 ProGlyPro, Synthetic analog of ACTH, Spinal Cord Injury, Locomotor function.

Abstract

Spinal Cord Injury could lead to immobility, paralyze, financial burden due to the high cost of treatments, even emotional disturbance, and distress. It has been a health problem over the years. The primary goal in treating Spinal Cord Injury (SCI) is to prevent secondary lesions of inflammation, thus prevent further disability. A synthetic analog of ACTH (ACTH 4-10 ProGlyPro) does not have hormonal activity, but it stimulates expression of BDNF (Brain-derived Neurotropic Factor), which showed to be a potent modulator of synaptic plasticity in the astrocytes. This research wanted to focus on ACTH 4-10 ProGlyPro

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Published

2017-05-24

How to Cite

Sim, A. S., Patellongi, I., Yusuf, I., As’ad, S., Wahid, S., Aulina, S., Kabo, P., sajuthi, D., & Islam, A. A. (2017). The Effect of ACTH 4-10 ProGlyPro as Anti-inflammatory on Astrocyte Cell Repair in Spinal-Cord-Injured Mouse by Assessing Locomotor Function. International Journal of Sciences: Basic and Applied Research (IJSBAR), 33(3), 31–41. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/7459

Issue

Vol. 33 No. 3 (2017)

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Articles

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