Comparative Effectiveness of 0.25% Turmeric Extract Cream and Grated Turmeric on Skin Elasticity Turmeric (Analysis of Curcuma Longa Concentration in Topical Preparations)

  • Roby Syah Putra Firmansyah Department of Dermatology and Venereology, Faculty of Medicine, Hassanuddin University, Makassar
  • Faridha S Ilyas Department of Dermatology and Venereology, Faculty of Medicine, Hassanuddin University, Makassar
  • Nurelly Nurelly Department of Dermatology and Venereology, Faculty of Medicine, Hassanuddin University, Makassar
  • Arifin Seweng Department of Biostatistic, Faculty of Public Health, Hassanuddin University, Makassar
  • Khaeruddin Djawad Department of Dermatology and Venereology, Faculty of Medicine, Hassanuddin University, Makassar
  • Gemini Alam Department of Pharmacognosy and Phytochemistry , Faculty of Pharmacy, Hassanuddin University, Makassar
Keywords: yellow turmeric (curcuma longa), 0.25% turmeric extract cream, skin elasticity.


Turmeric as an antioxidant has been emerging studied for its many uses, especially for the health aspect, especially in counteracting free radicals. This study aims to determine the effectiveness of 0.25% turmeric extract cream and grated yellow turmeric (Curcuma longa) in improving skin elasticity after skin application for 21 days. The experiment was conducted in a Hasanuddin University Hospital in Makassar from March 2017- April 2017. Prospective cohort method was preferred in an observational analytic study. The subjects are women aged 30-50 years old who visited the dermatovenereology outpatient department of Hasanuddin University Hospital. A total of 13 subjects are given 0.25% turmeric extract cream, grated yellow turmeric, and vitamin C creams for the control group. All the cream was applied once a day on the right arm above the appropriate marker that has been given. The same method was applied twice daily in the upper left arm. On day 8 and day 21 skin analyzer was used to measure the skin elasticity following cream application. The results showed no significant changes between the 0.25% turmeric extract cream and grated yellow turmeric applied once and twice a day. However, there is a tendency of increasing skin elasticity score on day 21 of 0.25% turmeric extract group.


. Garg A et al. Structure of Skin Lesions and Fundamentals of Clinical Diagnosis. In: Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffell, D. J. & Wolff, K. (eds.) Fitzpatrick

. Bennion S.D. Structure And Function Of The Skin. Dermatology Secret Plus. 4th ed. United Stase: ELSED.6-13. (2011).

. Fulop T et al. (The Role of Elastin Peptides in Modulating the Immune Response in Aging and Age-Related Pathologie Biologie. 60: 28-33. 2012).

. Kim S.H. et al. Research of Traditional Herbal Medicines for Anti-Aging, Inhibition Effect of Wrinkle and Whitening Effect in the Skin. Journal of Physiology & Pathology in Korean Medicine. (2008).

. Seo J.E et al. Ultraviolet Irradiation Induces Thrombospondin-1 which Attenuates Type I Procollagen Downregulation in Human Dermal Fibroblasts. Journal of Dermatological Science. 59: 16-24. (2010).

. Sirerol J.A. Topical Treatment With Pterostilbene, a Natural Phytoalexin, Effectively Protects Hairless Mice Against UVB Radiation-Induced Skin Damage and Carcinogenesis. Free Radic Biol Med. 85: 1-11. (2015).

. Yaar M & Gilchrest B.A. Photoageing: Mechanism, Prevention and Therapy. Br J Dermatol. 157: 874-887. (2007).

. Yanhendri S.W.Y. Berbagai Bentuk Sediaan Topikal Dalam Dermatologi. Cermin Dunia Kedokteran. 194: 6. (2012).

. Ndiaye M et al. The Grape Antioxidant Resveratrol for Skin Disorders: Promise, Prospects, and Challenges. Archives of Biochemistry and Biophysics. 508: 164-170. (2011).

. Saraf S & Kaur C. Phytoconstituents as Photoprotective Novel Cosmetic Formulations. Pharmacognosy Reviews. 4: 1. (2010).

. Lucida H dkk. Pengaruh Virgin Coconut Oil (VCO) di dalam Basis Krim terhadap Penetrasi Zat Aktif. Jurnal Ilmiah Farmasi Volume 4. (2007).

. Martelli L et al.Composition for Cosmetic or Pharmaceutical-Dermatological Use. Google Patents.(2007).

. Prabawati A. Evaluasi Daya Penetrasi Etil p-Metoksisinamat Hasil Isolasi dari Rimpang Kencur (Kaempferia galanga L.) pada Sediaan Salep, Krim, dan Gel. (2015).

. Setiawati S. Perbandingan Antara Ekstrak Kunyit 0,25% Parutan Kunyit dan Hidroquinon 4% Terhadap Perubahan Warna Kulit. Hassanuddin University. (2016).

. Winarsi H dkk. Deteksi Aging pada Perempuan Berdasarkan Status Antioksidan. Majalah Kedokteran Bandung. 45: 141-146. (2013).