The Comparison of Salivary Alpha Amylase Enzym Level Between Anxiety Patients and Depression Patients
Keywords:
anxiety, depression, salivary alpha amylase.Abstract
Salivary ?-amylase (sAA) serves as a marker of sympathoadrenal medullary system (SAM) activity. Research on the comparison of salivary ?-amylase levels between anxiety disorder and depression disorder had not been widely reported. In the current study, 30 anxiety patients, 30 depression patients and 30 healthy volunteers were assessed with Hamilton Anxiety Rating Scale (HARS) for anxiety patients and Hamilton Depression Rating Scale (HDRS) for depression patients. The measurement of the salivary ?-amylase (sAA) was performed before the anxiety patients and the depressed patients received treatment. Salivary ?-amylase (sAA) of the anxiety and depression patients group increased significantly compared to the control group (healthy people). There was a significant correlation between the scores of HARS and of HDRS to the level of sAA enzyme. Regression analysis indicated a potential increase of the sAA level in the amount of 5.673 kU/L per one score of HARS and one additional score of HDRS also potentially increased in the amount of 0.925 kU/L of the sAA enzyme level. Additionally, R2 obtained from linear regression for anxiety patients group was 0.442 which meant that the effect of HARS score on sAA was 44.2% and 55.8% sAA rate was influenced by other variables. R2 for depression patients group was 0.457 which meant that the effect of HDRS score to the level of sAA enzyme was 45.7 % and 54.3 % was influenced by other variables.
References
Riskesdas, "Mental Health in Agency for Research and Development of Health Ministry of Health," 2013.
Kaplan, H.I., and B.J. Sadock , "Mood Disorders in Psychiatric Synopsis," Eds 7. Jakarta. EGC pp. 52-144, 2010.
Maramis, W.F., "Mental Health Records," Surabaya. Airlangga University. , pp. 215-235, 1998.
Putra, S.T., "Biological Perception of Psychoneuroimunology of Medicine.," Eds 2. Unair Publishing and Printing Center, Surabaya , 2011.
Ali, N., J. Pruessner, "The Salivary Alpha Amylase Over Cortisol Ratio as a Marker to Asses Dysregulation of the Stress Systems," Physiology & Behavior, 106: 65-72, 2012.
Guyton and Hall., "Textbook of Medical Physiology. Eds 9. Jakarta," EGC. 58: 929-942, 1997.
Zakowski,J.J, and D.E., Bruns, "Biochemistry of Human Alpha Amylase Isoenzym," Crit Rev Clin Lab Sci. 21: 283-322, 1985.
Amerogen, A.V., "Saliva and Salivary Glands Mean for Dental Health. Interpretation by Rafiah Abyono," Yogyakarta: Gajah Mada University Press., 1998.
Nater, U.M., and N. Rohleder, "Salivary Alpha Amylase as a Non Invasive Biomarker for the Sympathetic Nervous System: Current State of Research. ," Psychoneuroendocrinology. 34: 469-485, 2009.
Inagaki, T., T. Miyaoka, S. Okazaki, H. Yasuda, T. Kawamukai, E. Utani., "High Salivary Alpha Amylase Levels in Patient with Schizophrenia: a Pilot Study. Prog. Neuropsychopharmacol Biol Psychiatry. ," 34: 688-691, 2010.
Tanaka, Y., Y. Ishitobi, Y. Maruyama, A. Kawano, T. Ando, J. Imanaga, et al., "Salivary Alpha Amylase and Cortisol Responsiveness Following Electrical Stimulation Stress in Major Depressive Disorder Patients, Neuropsychopharmaco Biol Psychiatry.," 36: 220-224, 2012.
Yamaguchi, M., T. Kanemori, M. Kanemaru, N. Takai, Y. Mizuno, H. Yoshida, "Performance Evaluation of Salivary Alpha Amylase Activity Monitor in Biosensors and Bioelectronics," 20: 491-497, 2004.
Schumacher, S., C. Kirschbaum, T. Fydrich, A. Strohle, "Is Salivary Alpha Amylase an Indicator of Autonomic Nervous System Dysregulation in Mental Disorder? A revieuw 37 of Preliminary Findings and the Interaction with Cortisol. ," Psychoneuroendocrinology ; 38: 729-743, 2013.
Veen, J.F., I.M. Van, R.H. Derijk, P.J. Van, B. Mertens,F.G. Zitman, "Elevated Alpha-Amylase bu not Cortisol in Generalized Social Anxiety Disorder.," Psychoneuroendocrinology ; 33: 1313-1321, 2008.
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