Pathophysiological Changes Occuring in Cardiovascular and Immune Systems In Response to Stress

  • Mahmoud H. El-Bidawy Department of BMS, Division of Physiology, College of Medicine, Al-Kharj, Prince SattamIbnAbdulaziz University. Department of Medical Physiology, Faculty of Medicine, Cairo University,Cairo, Egypt
Keywords: Stress, Pathophysiology of Cardiovascular diseases, Pathophysiology of Immune system.


Cardiovascular and immune system pathophysiological changes and diseases  may be attributed to stress. Sometimes stress may be beneficial when it is not 'overwhelming' as it ,may improve performance in certain cases. Modern medicine is focusing on the close relationship between stress and cardiovascular and immune system morbidity  and mortality. New therapeutic strategies have to be set in place.Brief naturalistic stressors (such as exams) were associated with potentially adaptive upregulation of some parameters of natural immunity and downregulation of some functions of specific immunity; tended to suppress cellular immunity while preserved humoral immunity On the other hand chronic stressors were associated with suppression of both cellular and humoral immunity. In some cases, physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.In mammals, physiological responses such as “fight or flight.” to chronic stressors , include changes that increase the delivery of oxygen and glucose to the heart and the large skeletal muscles. The changes in Immune responses to stressful situations may be part of these adaptive responses..Pychological challenges are capable of modifying various features of the immune response.


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