Pathophysiological Changes Occuring in Cardiovascular and Immune Systems In Response to Stress

  • Mahmoud H. El-Bidawy Department of BMS, Division of Physiology, College of Medicine, Al-Kharj, Prince SattamIbnAbdulaziz University. Department of Medical Physiology, Faculty of Medicine, Cairo University,Cairo, Egypt
Keywords: Stress, Pathophysiology of Cardiovascular diseases, Pathophysiology of Immune system.

Abstract

Cardiovascular and immune system pathophysiological changes and diseases  may be attributed to stress. Sometimes stress may be beneficial when it is not 'overwhelming' as it ,may improve performance in certain cases. Modern medicine is focusing on the close relationship between stress and cardiovascular and immune system morbidity  and mortality. New therapeutic strategies have to be set in place.Brief naturalistic stressors (such as exams) were associated with potentially adaptive upregulation of some parameters of natural immunity and downregulation of some functions of specific immunity; tended to suppress cellular immunity while preserved humoral immunity On the other hand chronic stressors were associated with suppression of both cellular and humoral immunity. In some cases, physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.In mammals, physiological responses such as “fight or flight.” to chronic stressors , include changes that increase the delivery of oxygen and glucose to the heart and the large skeletal muscles. The changes in Immune responses to stressful situations may be part of these adaptive responses..Pychological challenges are capable of modifying various features of the immune response.

References

. Esch T: Health in Stress: Change in the Stress Concept and its Significance for Prevention, Health and Life Style. Gesundheitswesen, 2002; 64: 73-81

. Selye H: The Physiology and Pathology of Exposure to Stress. Acta Inc. Medical Publishers, Montreal, 1950.

. Selye H: The Evolution of the Stress Concept. American Scientist, 1973; 61: 692-699

. Jones F, Bright J, Clow A: Stress: Myth, Theory and Research. Prentice Hall, New York, 2001.

. Esch T: Bestimmung von Vorgaengenzumaktiven Erhalt der zellulaerenAutonomie und OrganisationmitHilfe des Schwesterchromatid-Austausch-Verfahrens [Dissertation]. GeorgAugust-Universitaet, Goettingen, 1999.

. McEwen BS: Protective and damaging effects of stress mediators. New England Journal of Medicine, 1998; 338: 171-179.

. Esch T, Stefano GB, Fricchione GL, Benson H: An Overview of Stress and Its Impact in Immunology.

. Vogel WH, Bower DB: Stress, immunity and cancer. In: Plotnikoff NP, Margo AJ, Faith RE, Wybran J eds: Stress and immunity. CRC Press, Boca Raton, 1991; 493-507.

. Stefano GB, Cadet P, Zhu W et al: The blueprint for stress can be found in invertebrates. Neuroendocrinology Letters,2002 .

. Cannon W: The emergency function of the adrenal medulla in pain and the major emotions. American Journal of Physiology, 1914; 33: 356-372.

. Cannon WB: Bodily changes in pain, hunger, fear, and rage; an account of recent researchers into the function of emotional excitement. Appleton and Company, New York, London, 1915.

. Negrao AB, Deuster PA, Gold PW et al: Individual reactivity and physiology of the stress response. Biomedical Pharmacotherapy, 2000; 54: 122-128.

. McCarty R, Gold P: Catecholamines, Stress, and Disease: A Psychobiological Perspective. Psychosomatic Medicine, 1996; 58: 590-597.

. Newlin DB, Levenson RW: Cardiovascular responses of individuals with type A behavior pattern and parental coronary heart disease. Journal of Psychosomatic Research, 1982; 26: 393-402.

. Nishi N, Nanto S, Shimai S et al: Effects of hostility and lifestyle on coronary heart disease among middle-aged urban Japanese. Journal of Epidemiology, 2001; 11: 243-248.

. Le Melledo JM, Arthur H, Dalton J et al: The influence of Type A behavior pattern on the response to the panicogenic agent CCK-4. Journal of Psychosomatic Research, 2001; 51: 513-520.

. Myrtek M: Meta-analyses of prospective studies on coronary heart disease, type A personality, and hostility. International Journal of Cardiology, 2001; 79: 245-251.

. Suarez EC, Williams Jr RB, Kuhn CM et al: Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity. Psychosomatic Medicine, 1991; 53: 528-537.

. Krantz DS, Kop WJ, Santiago HT, Gottdiener JS: Mental stress as a trigger of myocardial ischemia and infarction. Cardiology Clinics 1996; 14: 271-287.

. Strawn WB, Bondjers G, Kaplan JR et al: Endothelial dysfunction in response to psychosocial stress in monkeys. Circulation Research, 1991; 68: 1270-1279.

. Curtis BM, O’Keefe Jr JH: Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clinic Proceedings, 2002; 77: 45-54 .

. Wenneberg SR, Schneider RH, Walton KG et al: A controlled study of the effects of the Transcendental Meditation program on cardiovascular reactivity and ambulatory blood pressure. International Journal of Neuroscience, 1997; 89: 15-28.

.Lutgendorf S, Logan H, Kirchner HL et al: Effects of relaxation and stress on the capsaicin-induced local inflammatory response. Psychosomatic Medicine, 2000; 62: 524-534/

. Sanders BJ, Lawler JE: The borderline hypertensive rat (BHR) as a model for environmentally-induced hypertension: a review and update. Neuroscience and Biobehavioral Reviews, 1992; 16: 207217.

-Miller GE, Cohen S. Psychological interventions and the immune system: A meta-analytic review and critique. Health Psychology 2001;20:47– 63. [PubMed: 11199066].

-Bower JE, Kemeny ME, Taylor SE, Fahey JL.Cognitive processing, discovery of meaning, CD4 decline, and AIDS-related mortality among bereaved HIV-seropositive men. Journal of Consulting and Clinical Psychology 1998;66:979–986. [PubMed: 9874911].

-Miller GE, Dopp JM, Myers HF, Stevens SY, Fahey JL.Psychosocial predictors of natural killer cell mobilization during marital conflict. Health Psychology 1999;18:262–271. [PubMed: 10357507].

-Bachen EA, Manuck SB, Cohen S, Muldoon MF, Raible R, Herbert TB, Rabin BS. Adrenergic blockade ameliorates cellular immune responses to mental stress in humans. Psychosomatic Medicine 1995;57:366–372. [PubMed: 7480566].

-Benschop RJ, Nieuwenhuis EES, Tromp EAM, Godaert GLR, Ballieux RE, van Doornen LJP.Effects of β-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress. Circulation 1994;89:762–769. [PubMed: 7508828].

-Miller GE, Cohen S, Herbert TB.Pathways linking major depression and immunity in ambulatory female patients. Psychosomatic Medicine 1999;61:850– 860. [PubMed: 10593638].

-Miller GE, Stetler CA, Carney RM, Freedland KE, Banks WA.Clinical depression and inflammatory risk markers for coronary heart disease. American Journal of Cardiology 2002;90:1279–1283. [PubMed: 12480034].

-Cover H, Irwin M. Immunity and depression: Insomnia, retardation, and reduction of natural killer cell activity. Journal of Behavioral Medicine 1994;17:217–223. [PubMed: 8035453].

-Hall M, Baum A, Buysse DJ, Prigerson HG, Kupfer DJ, Reynolds CF III. Sleep as a mediator of the stress-immune relationship. Psychosomatic Medicine 1998;60:48–51. [PubMed: 9492239] Hall et al., 1998.

- Cohen S, Doyle WJ, Skoner DP. Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosomatic Medicine 1999;61:175–180. [PubMed: 10204970].

- Bower JE, Kemeny ME, Taylor SE, Fahey JL. Cognitive processing, discovery of meaning, CD4 decline, and AIDS-related mortality among bereaved HIV-seropositive men. Journal of Consulting and Clinical Psychology 1998;66:979–986. [PubMed: 9874911].

- Miller GE, Cohen S, Ritchey AK. Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid resistance model. Health Psychology 2002;21:531–541. [PubMed: 12433005].

- Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annual Review of Medicine 2000;51:245–270.

- Busse WW, Lemanske RF. Advances in immunology: Asthma. New England Journal of Medicine 2001;344:350–362. [PubMed: 11172168.

. Black PH, Garbutt LD: Stress, inflammation and cardiovascular disease. Journal of Psychosomatic Research, 2002; 52: 1-23 .

. Joho S, Asanoi H, Takagawa J et al: Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia. Journal of the American College of Cardiology, 2002; 39: 436-442.

. Shimizu M, Ino H, Yamaguchi M et al: Heterogeneity of cardiac sympathetic nerve activity and systolic dysfunction in patients with hypertrophic cardiomyopathy. Journal of Nuclear Medicine, 2002; 43: 15-20.

. Malliani A, Montano N: Emerging excitatory role of cardiovascular sympathetic afferents in.

. Stefano GB, Murga J, Benson H et al: Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta. Pharmacological Research, 2001; 43: 199-203.

. Alvarez A, Piqueras L, Bello R et al: Angiotensin II is involved in nitric oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelial cell interactions in vivo. British Journal of Pharmacology, 2001; 132: 677-684.

. Alvarez G, Osuna A, Wangensteen R, Vargas F: Interaction between nitric oxide and mineralocorticoids in the long-term control of blood pressure. Hypertension, 2000; 35: 752-757.

.Nedic O, Filipovic D, Solak Z: Job stress and cardiovascular diseases with health workers. Medicin ski Pregled, 2001; 54: 423-431.

. Fricchione GL, Bilfinger TV, Hartmann A et al: Neuroimmunologic implications in coronary artery disease. Advances in Neuroimmunology, 1996; 6: 131-142.pathophysiological conditions. Hypertension, 2002; 39: 63-68.

. Arnetz BB: Technological stress: psychophysiological aspects of working with modern information technology. Scandinavian Journal of Work and Environmental Health, 1997; 23: S97-S103.

. Stefano GB, Fricchione GL, Slingsby BT: Is stress stress? Placebo, 2001; 3: 101-110.

. Stefano GB, Fricchione GL, Slingsby BT, Benson H: The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Research Reviews, 2001; 35: 1-19.

Published
2018-11-29
Section
Articles