@article{magdy_Fathalla_Alaaeldin_F. Mansour_2021, title={Formulation and In-vitro Characterization of Metformin Hydrochloride-loaded Liposomes}, volume={56}, url={https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/12330}, abstractNote={<p><strong>The aim of study.</strong> is to formulate Metformin hydrochloride-loaded novel liposomal vesicles and investigate their physical stability. A new metformin hydrochloride (Met-HCL) liposomal formulation was prepared  for topical delivery. Traditionally, the biguanide metformin could be categorized the first line in treatment of diabetes. The prepared metformin hydrochloride-loaded liposomal vesicles were investigated  for different in vitro characterisations. Eleven different formulations were developed adopting a thin film hydration method using different molar concentrations of Phospholipon® 90G, cholesterol and metformin hydrochloride. The effect of varying concentrations of Phospholipon® 90G, cholesterol and metformin hydrochloride on entrapment efficiency percent, ex-vivo skin permeation percentage, vesicle size and zeta potential was studied. Metformin-loaded liposome stability over a period of time 90 days was investigated. <strong>Results.</strong> The optimized metformin hydrochloride liposomes, F2, F6 and F11 were selecte. The selected formulations displayed highly efficient permeation percent via the excised mice skin 53±0.09 %, 30±0.4 % and 40±0.02 % respectively. The formulations showed EE % of  80±0.09 %, 28.6±0.02 % and 71.8±0.4 % respectively. Morphology of F2  liposomal surface revealed spherical three-dimensional structure. The stability study revealed about 10-23 percent drug leaching out of the vesicular liposomes (F2) within 90 days. <strong>Conclusion. </strong>Metformin hydrochloride-loaded liposomal vesicles can provide a potentially promising and convenient approach for topical delivery.</p>}, number={1}, journal={International Journal of Sciences: Basic and Applied Research (IJSBAR)}, author={magdy, Shrouk and Fathalla, Zeinab and Alaaeldin, Eman and F. Mansour, Heba}, year={2021}, month={Feb.}, pages={150–164} }