TY - JOUR AU - Garige, Anil Kumar AU - Garlapati, Achaiah PY - 2016/12/12 Y2 - 2024/03/28 TI - Synthesis and Evaluation of New Series of 1,4-Dihydropyridine Derivatives as Anticancer Agents JF - International Journal of Sciences: Basic and Applied Research (IJSBAR) JA - IJSBAR VL - 30 IS - 5 SE - Articles DO - UR - https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/6666 SP - 87-97 AB - <p class="Els-Abstract-text">1,4-dihydropyridine derivatives represent one of the important classes of compounds possessing a wide variety of biological activities including anticancer activity. In the present study, (4-Alkyl/Aryl-1-substituted 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxilicacid, 3,5-bis [2(aminothioxomethyl)hydrazides]) (6 a-l) were synthesized by the reaction of 4-alkyl/aryl-3,5-dicarboalkoxy-2,6-dimethyl-1,4-dihydropyridines (4 a-l) with thisemicarbazide and evaluated for their anti-cancer properties.</p> <p class="Els-Abstract-text">All the synthesized compounds were characterized by IR, NMR and Mass spectra and were screened to evaluating for anticancer activity against three cell lines (MCF-7, HeLa and Hep G<sub>2</sub>) by using MTT assay method. The results showed that compounds 6j and 6l showed significant cytotoxicity with IC<sub>50</sub> values ranging from 56 ER -