International Journal of Sciences: Basic and Applied Research (IJSBAR)

Practice of Fiducial Marker in Prostate Cancer: A Single-Center Experience with up to 6 Years’ Follow-up Results

2021-09-18T15:35:11+00:00

We aimed to evaluate the long-term follow-up results of patients with prostate cancer implanted with ultrasound-guided fiducial marker(FM). Forty patients, between 2012-2017 were evaluated. Firstly, the gastrointestinal-genitourinary system side effects were questioned twice immediately after FM implant and in the median 6.5th year and the grading was performed via the NCI CTCAE-V5.0 test and compared. Secondly, in the late period, questions assessing genitourinary-gastrointestinal symptoms were asked using the EORTC QLQ-PR25 Module,and the complication status and patient comfort were assessed The mean symptom value for all patients in the EORTC QLQ-PR25 module was 17,33%. In the first assessment made according to the results obtained by questioning the genitourinarygastrointestinal symptoms related to the FM procedure both after the procedure and in the median 6.5th year,rectal bleeding was present in 2(4%),dysuria 3(6%),hematuria 5(11%) and frequency of urination in 5(11%) patients and in the second assessment,no new symptoms were added and the overall symptom rate decreased. In the first assessment,it was determined via NCI CTCAE-V 5.0 scale that the adverse effects of 9 patients (20%),who were identified with adverse effects,were grade 1 corresponding to mild side effects,and none of the patients experienced grade 2 or higher adverse events. In the second assessment,side effects were defined in 3 patients (7,5%) and grade 1 was mild. The ultrasound-guided FM implant procedure,which is used in prostate cancer radiotherapy is an easy,tolerable and safe technique that does not lead to adverse effects and loss of comfort in patients with long-term follow-up

Is the National Accreditation System Sufficient? Critique of the System in the United States to Vietnam and Japan Japan Foundation Japan Studies Through Collaboration

2021-09-17T16:56:52+00:00

Higher education has jumped into the quality movement with expectations of enhancing the excellence of education being received by students. Higher education institutions are becoming a business while knowledge is becoming the commodity, with all aspects of education subject to global trade. There is a need for education to become more efficient, self-sufficient, and accountable. Neo-liberalism reduces governmental subsidies, while shifting costs to the market and consumers. Furthermore, it demands accountability for performance, and emphasize higher education’s role in the economy. The injection of accountability and accreditation into the educational system is necessary for a quality global educational system. This paper looks at the development of national accreditation within the United States, Vietnam, and Japan. Developing an understanding of the accreditation process will contribute to the literature surrounding accreditation and quality assurance.

Genetic Characterization of the Kada-Goudami Lineage for the Improvement of Onion (Allium cepa L.) Cultivation in the Sudano-Sahelian Zone of Cameroon

2021-09-16T14:08:42+00:00

The objective of this study is to analyze the possibilities of growing the Kada-Goudami lineage for improved onion production in the Sudano-Sahelian zone of Cameroon. From multi-location trials conducted during the 2019 to 2020 rainy and dry seasons at the Nguetchewe, Palar and Pitoa sites. Yield and phenology characteristics were evaluated to select the Kada-Goudami lineage as a "rescue seed, catch-up cultivar or alternative crop". The popularized varieties (El Kara, Goudami and Violet de Galmi) served as controls. Vegetative development, phenology and yield components of the different genotypes were evaluated and compared in a randomized complete block design in each site during the two seasons. Extended heritability values and expected gains from selection were determined. Variance analyses show the significant differences between the genotypes tested. The mean value of heritability of the studied traits is overall high (h² ≥ 0.84) and the expected gains from selection are relatively appreciable. This shows the possibility of effective selection and genetic improvement. The Kada-Goudami lineage appears to be better adapted to the dry season in our growing area, but it can also be used as a cool season crop (October-January).

Résumé : L’objectif de cette étude est d’analyser les possibilités de culture de la lignée Kada-Goudami pour une amélioration de la production de l’oignon en zone soudano-sahélienne du Cameroun. A partir des essais multilocaux conduits au cours de la saison pluvieuse et sèche en 2019 et 2020, sur les sites de Nguetchewe, Palar et Pitoa. Les caractéristiques du rendement et de la phénologie ont été évaluées en vue de sélectionner la lignée Kada-Goudami comme « semence secours ou cultivar de rattrapage voire culture alternative ». Les variétés vulgarisées (El Kara, Goudami et le Violet de Galmi) ont servi des témoins. Le développement végétatif, la phénologie et les composantes du rendement des différents génotypes ont été évalués et comparés dans un dispositif en blocs complets randomisés dans chaque site pendant les deux saisons. Les valeurs d’héritabilité au sens large et les gains attendus de la sélection ont été déterminées. Les analyses de variance montrent les différences significatives entre les génotypes testés. La valeur moyenne de l’héritabilité des caractères étudiés est globalement élevée (h² ≥ 0,84) et les gains attendus de sélection sont relativement appréciables. Ce qui montre la possibilité d’une sélection efficace et d’amélioration génétique. La lignée Kada-Goudami semble mieux adaptée en saison sèche dans notre zone de culture mais on peut aussi l’utiliser comme culture de saison fraiche (Octobre-Janvier). Cette étude montre que la lignée Kada-Goudami est prometteuse pour améliorer la production de l’oignon en milieu soudano-sahélienne du Cameroun.

The Use of Cannabinoids in the Management of Chronic Pain: A Perceptual Survey among Practitioners

2021-09-14T14:10:16+00:00

The management of chronic pain represents a challenge due to limitations and side effects associated with conventional treatments. Thus, the introduction of medical cannabis represents a new effective strategy. The purpose of this study is to investigate the acceptability of medical cannabis among practitioners and evaluate its limitations and obstacles to its use in medicine. We collected the data through a questionnaire that targeted doctors (neurologists and oncologists) in major university hospitals and private practices. The results of our study showed that the most important limitations to the use of conventional treatment are end-of-dose failure and resistance to treatment. We also found that the lack of clinical studies, the risk of addiction and mental illness represent the principal limitations to the use of medical cannabis. In addition, our study confirmed that the major obstacles to the introduction of cannabinoids in the pharmaceutical market are related to legislation, religion, and social stigmatization. Despite these limitations and barriers, most Moroccan doctors are favorable to its prescription without fear of legal persecution. Our study, the firstone of its kind in North Africa, provides essential data regarding the acceptability of its medical use and represents a starting point for more in-depth research.

Faith and Responsibility in Individual Sovereignty

2021-09-17T04:57:54+00:00

This paper deals with two conceptual problems of individual sovereignty as pointed out by Duffel (2007) and Duffel (2004), that I call as “theoretical problem” and “aberration problem” respectively. The concept of sovereignty in general, and individual sovereignty in particular, suffered serious theoretical problems that seem irresolvable. But arguably it is a concept with great operational success as proven by four centuries of Western civilization dominance. How can a concept achieve such an operational success yet conceptually flawed? The second problem of sovereignty is related to the objections that it places too much weight on rights. To address both these conceptual problems this paper will resort to the teaching of Jordan Peterson, and speculates that what underpins the concept itself is that of faith as opposed to reason, and argues for the return to the more classical version of it that focuses more on responsibility. It concludes that Christians ought to give more serious thought on individual sovereignty as its manifestation is arguably the greatest gift from Judeo-Christian tradition to mankind, especially in the sphere of socio-politic.