Comparison of IL-6 and IL-10 Trombosite and Soluble Levels in Thrombocytopenia Post-transfusion Thrombopheresis

  • Sri Julyani Clinical Pathology Department, Faculty of Medicine, Hasanuddin University
Keywords: thrombocytopenia, platelet transfusion, IL-6, IL-10

Abstract

Thrombocytopenia can occur due to tumors in the bone marrow, spleen, or both. Other factors such as myeloablative and non-myeloablative chemotherapy, drugs, dosage, and the number of therapeutic cycles and immune disorders. Platelet transfusion is indicated to prevent or treat bleeding due to thrombocytopenia. This study aims to analyze the relationship between thrombocyte posttransfusion platelet levels with IL-6 and IL-10 levels in thrombocytopenia patients. Respondents consisted of 14 patients who were measured platelet levels pre and posttransfusion with a hematological analyzer and IL-6 and IL-10 levels by the ELISA method. The difference in the number of pre and post-transfusion platelet platelets with mean pre-transfusion platelet levels is 12,937 cells / ?l, and the average post-transfusion platelet level is 80,062 cells / ?l. Posttransfusion thrombogenesis decreased IL-6 levels with a minimum level of 12.487 pg/ml and a maximum level of 161.325 pg/ml and posttransfusion IL-10 levels decreased with a minimum level of 7,431 pg/ml and a maximum cadr of 55.868 pg/ml. The results showed an increase in platelet levels accompanied by decreased levels of IL-6 and IL-10 showed a reduction in inflammatory reactions caused by platelet function in improving the immune response.

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Published
2019-08-14
Section
Articles