Formulation and Characterization of Thymoquinone Bioadhesive Gel for Treatment of Chronic Gum Inflammation

Authors

  • Eman alaaeldin Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 19623, Egypt
  • Nael Kamel Eltewacy Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 19623, Egypt
  • Amna Ali Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 19623, Egypt
  • Mohamed Diaa Gomaa Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 19623, Egypt
  • Ahmed Abdallah Khalil Lecturer of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Minia University,Minia 19623, Egypt

Keywords:

periodontitis, TQ, bioadhesive gel, IL-1β, clinical parameters

Abstract

The aim of study is to formulate Thymoquinone gel and investigate its effect in chronic periodontitis in terms of clinical periodontal parameters, anti-oxidant capacity and the levels of IL-1? in gingival crevicular fluid. different gelling agents (carbopol, hydroxyl propyl methyl cellulose and chitosan) were used for the development of TQ gel. The optimized gel formulation was used for the clinical study. The study was conducted on 68 subjects (25-58 years old). 48 patients were clinically diagnosed with moderate to severe chronic periodontitis. Patients were divided into three groups; Group I (24 patients): received non-surgical periodontal therapy and Thymoquinone-chitosan gel (0.1 % w/w), Group II (24 patients): received only non-surgical periodontal therapy and Group III: 20 healthy subjects (control group). All patients were evaluated for clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment level (CAL).  The levels of IL-1? and total anti-oxidant capacity were recorded in gingival crevicular fluid at baseline (prior to treatment) and at weeks 4 and 12 after treatment. The results showed that combination of non-surgical periodontal therapy and Thmoquinone gel (group I)  exhibited statistically significant improvement in biochemical parameters compared to non-surgical periodontal therapy alone (group II).

In conclusion we can say that the adjunctive use of thymoquinone gel with non-surgical periodontal therapy improves the biochemical parameters accompanied with chronic periodontitits significantly after 4 weeks only.

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Published

2017-01-10

How to Cite

alaaeldin, E., Eltewacy, N. K. ., Ali, A. ., Gomaa, M. D. ., & Khalil, A. A. . (2017). Formulation and Characterization of Thymoquinone Bioadhesive Gel for Treatment of Chronic Gum Inflammation. International Journal of Sciences: Basic and Applied Research (IJSBAR), 31(2), 321–330. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/10554

Issue

Vol. 31 No. 2 (2017)

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Articles

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