Root/Stem Extracts of Glycyrrhiza glabra; As a Medicinal Plant Against Disease Forming Microorganisms

Authors

  • Dissanayake KGC Department of Cikitsa, Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, Yakkala 11870, Sri Lanka
  • Weerakoon WMTDN Department of Chemistry, University of Kelaniya, Dalugama, Kelaniya 11600, Sri Lanka
  • Perera WPRT Research & Publication Division, Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, Yakkala 11870, Sri Lanka

Keywords:

pharmacology, phytochemical, medicinal plant, Glycyrrhiza glabra

Abstract

Nature is one of the major sources of medicines since the beginning of human civilization. Different counties around the globe have been used different plant materials to overcome varieties of ailments from simple cough to hepatitis to more complexes like SARS and most recently Covid 19. This review is an effort to emphasis the phytochemical and chemical constituents of G. glabra and their mechanisms against disease forming microorganisms. This traditional plant which is well known in Sri Lanka as “Welmi” is belongs to family Leguminosae/ Fabaceae. Chemical constituents of G. glabra like isoliquiritine, isoflavones, glycyrrhetic acid, saponin and their derivatives have been examined for their pharmacological activities. Most critical chemical compounds which isolated from the root/stem extract of the G. glabra are Glycyrrhizin and Glycyrrhetic acid. Glycyrrhizin is a prominent triterpenoid contain in Glycyrrhiza glabra which is responsible for the sweet taste of its roots. Glycyrrhizin act as anti-viral compound in two ways. It is able to inhibit the replication process of some RNA viruses such as SARS like corona type virus. Another process is acting as an immunostimulator. It has been used to treat patients suffering from chronic hepatitis C virus and HIV-1 patients owing to its capability of stimulating endogenous viral defense mechanisms.

Another important phytochemical called Glycyrrhizic acid is a natural saponin composed of hydrophilic part, hydrophobic fragment, two molecules of glucuronic acid and glycyrrhetic acid. Apart from that some other isolated compounds like hispaglabridin B, 40-methylglabridin, glabridin, gabrin, 3-hydroxyglabrol and glabrene exhibits serious anti-bacterial actions. In addition, plant extract's chemicals have antidiabetic, antibiotic, antiviral, anti-inflammatory, anticancer, antiulcer and anti-demulcent activities as well. Finally, the phytochemicals present in G. glabra will perform a promising role in the development of new herbal drugs against disease forming virus and bacteria species as well as their derivatives are being generated to evaluate their pharmacological purposes for future drug use.

References

. J. Bruneton. Pharmacognosy, phytochemistry, medicinal plants. Paris: Lavoisier Publishing, 1995, pp. 915. A.Y. Leung and S. Foster. Encyclopedia of common natural ingredients used in food, drugs and cosmetics, 2nd ed. New York: John Wiley & Sons, In, 1996.

. N. Mohammad and S. Rehman. “Performance of Glycyrrhiza glabra in Mastung valley, Baluchistan”. Pakistan Journal of Agricultural Research, vol. 6(3), pp. 176-179, 1985.

. K. Usmanghani. Researches on Materia Medica. Department of Pharmacognosy. Faculty of Pharmacy. University of Karachi, 1997, pp.29-35

. S.M. Goodman and A. Ghafoor. “The ethno botany of Southern Balouchistan, Pakistan, with particular reference to medicinal plants”. Fieldiana Botany, vol. 31 (1- V): pp. 1-84, 1992.

. K. Bone. “Liquorice the universal herb”. The British Journal of Phytotherapy, vol 1(2), pp. :7-13, 1990.

. M. Parle, D. Dhingra and S.K. Kulkarni. “Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interceptive behavioral models”. Journal of Medicinal Food, vol 7(4), pp. 462-466, 2004.

. D.I. Anilkumar, J. Hemang and K. Nishteswar. “Review of Glycyrrhiza glabra (yastimadhu) - abroad spectrum herbal drug”. An International Journal of Pharmaceutical Sciences, 2012.

. H. Seki, O. Kiyoshi, S. Sawai, M. Mitzutani, T. Ohnishi, H. Sudo, et al. “Licorice β-amyrin 11- oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin”, in Proc. National Academy of Sciences of the USA, vol. 105 (37), 2008, pp. 14204-14209.

. V. Sharma and R. C. Agrawal. “Glycyrrhiza glabra: a plant for the future”. Mintage Journal of Pharmaceutical and Medical Sciences, vol. 2(3), pp.15–20, 2013.

. M. Griffiths, 1963. A. Huxley. New RHS dictionary of gardening. Ed. London: Macmillan, 1992. ISBN 0-333-47494-5

. A. Olukoga and D. Donaldson. “Historical perspectives on health. The history of liquorice: the plant, its extract, cultivation, and commercialization and etymology”. Journal of Royal Society for the Promotion of Health, 1998, vol. 118, pp. 300–304.

. P.R. Bradley. British herbal compendium, vol 1. Bournemouth: British Herbal Medicine Association, 1992.

. D. Hoffmann. The new holistic herbal, 2nd ed., 1990, Shaftesbury: Element, pp. 10.

. G.V. Obolentseva, V.I. Litvinenko, A.S. Ammosov, T.P. Popova and A.M. Sampiev. “Pharmacological and therapeutic properties of licorice preparations (a review)”. Pharmaceutical Chemistry Journal, vol. 33, pp. 24–31, 1999.

. Y. Yamamura, J. Kawakami, T. Santa, H. Kotaki, K. Uchino, Y. Sawada, et al. “Pharmacokinetic profile of glycerrhizin in healthy volunteers by a new high-performance liquid chromatographic method”. Jpurnal of Pharmaceutical Science, vol. 81(10), pp. 1042–1046, 1992.

. J. Vaya, P.A. Belinky, M. Aviram. “Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation”. Free Radical Biology and Medicine, vol. 23, pp. 302–313, 1997.

. S. Tamir, M. Eizenberg, D. Somjen, S. Izrael and J. Vaya. “Estrogen like activity of glabrene and other constituents isolated from licorice root”. Journal of Steroid Biochemistry and Molecular Biology. vol. 78, pp. 291–298, 2001.

. H. Hikino, H. Wagner and N. R. Farnsworth. Recent research on oriental medicinal plants. Economic and medicinal plant research, vol 1. London: Academic, pp 53–85, 1985.

. J. Kamei, R. Nakamura, H. Ichiki and M. Kubo. “Anti-tussive principles of Glycyrrhiza radix, a main component of Kampo preparations Bakumondo-to”. European Journal of Pharmacology, vol. 69, pp. 159–163, 2003.

. Y. Clinati and L.A. Blatina. “Chemical modification of glycyrrhizic acid as a route to bioactive compounds for medicine”. Current Medicinal Chemistry, vol. 10, pp. 155–171, 2003.

. L. Badam. “In vitro antiviral activity of indigenous glycyrrhizin, licorice and glycyrrhizic acid (Sigma) on Japanese encephalitis virus”. Journal of Community Diseases. Vol. 29, pp. 91–99, 1997.

. L. Badam. “In vitro studies on the effect of glycyrrhizin from Glycyrrhiza glabra on some RNA and DNA viruses”. Indian Journal of Pharmacology, vol. 26, pp. 194–199, 1994.

. T.G. Van Rossum, A.G. Vulto, R.A. De Man, J.T. Brouwer, S.W. Schalm. “Glycyrrhizin as a potential treatment of chronic hepatitis C”. Alimentary Pharmacological Therapy, vol. 12, pp. 199–205, 1998.

. V. Sharma, R.C. Agrawal and S. Pandey. “Phytochemical screening and determination of antibacterial and anti-oxidant potential of Glycyrrhiza glabra root extracts”. Journal of Environmental Research and Development, vol. 7 (4A), pp. 1552–1558, 2013.

. H. Haraguchi, K. Tanimato, Y. Tamura and T. Kinoshita. “Antioxidative and Superoxide scavenging activities of retrochalcones in Glycyrrhiza inflate”. Phytochemistry, vol. 48, pp. 125–129, 1998.

. L.A. Mitscher, Y.H. Park, D. Clark and J.L. Beal. “Antimicrobial agents from higher plants: antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var typical”. Journal of Natural Products, vol. 43, pp. 259–262, 1980.

. M. Saeedi, K. Morteza-Semnani, M.R. Ghoreishi. “The treatment of atopic dermatitis with licorice gel”. Journal of Dermatological Treatment, vol. 14, pp. 153–157, 2003.

. D.M. Biondi, C. Rocco and G. Ruberto. “New dihydrostilbene derivatives from the leaves of Glycycrrhiza glabra and evaluation of their anti-oxidant activity”. Journal of Natural Products, vol. 66, pp. 477–480, 2003.

. M.J. Masoomeh and G. Kiarash. “In vitro susceptibility of Helicobacter pylori to licorice extract”. Iranian Journal of Pharmaceutical Research, vol. 6, pp. 69–72, 2007.

. M. Adel, L.A. Alousi, H.A. Salem. “Licorice: a possible anti-inflammatory and anti-ulcer drug”. American Association of Pharmaceutical Scientists Pharmaceutical Science and Technology, vol. 6, pp. 74–82, 2005.

. M. Salvi, C. Fiore, D. Armanini and A. Toninello. “Glycyrrhetinic acid induced permeability transition in rat liver mitochondria”. Biochemical Pharmacology, vol. 66, pp, 2375–2379, 2003.

. C. Fiore, M. Salvi, M. Palermo, G. Sinigagliab, D. Armaninia and A. Toninello. “On the mechanism of mitochondrial permeability transition induction by glycyrrhetinic acid”. Biochimica Biophysica Acta, vol. 1658, pp. 195–201, 2004.

. M. Watanabe, S. Hayakawa, M. Isemura, S. Kumazawa, T. Nakayama, C. Mori, et al. “Identification of licocoumarone as an apoptosis inducing component in licorice”. Biological and Pharmaceutical Bulletin, vol. 25, pp. 1388–1390, 2002.

. V. Sharma and R.C. Agrawal. “Evaluation of Anticlastogenic effects of Glycyrrhiza glabra root extract against cyclophosphamide induced chromosomal aberration in swiss albino Mice”. Journal of Applied Pharmaceutical Science, vol. 5(6), pp. 127–132, 2015.

. C.Y. Hsiang, I.L. Lai, D.C. Chao and T.Y. Ho. “Differential regulation of activator protein-1 activity by glycyrrhizin”. Life Science, vol. 70, pp. 1643–1656, 2002.

. G. Yoon, Y.D. Jung and S.H. Cheon. “Cytotoxic allyl retrochalcone from the roots of Glycyrrhiza inflate”. Chemical and Pharmaceutical Bulletin, vol. 53, pp. 694–695, 2005.

. H. Takii, T. Kometani, T. Nishimura, T. Nakae, S. Okada and T. Fushiki. “Anti-diabetic effect of glycyrrhizin in genetically diabetic KK-Ay mice”. Biological and Pharmaceutical Bulletin, vol. 24, pp. 484–487, 2000.

. H. Wagner and K. Jurcic. “Immunological studies of Revitonil: a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract”. Phytomedicine, vol. 9(5), pp. 390–397, 2002.

. R. Arora, R. Chawla, R. Marwah, P. Arora, R.K. Sharma, V. Kaushik, et al. “Potential of complementary and alternative medicine in preventive management of novel H1N1 Flu (Swine Flu) pandemic: thwarting potential disasters in the bud”. Evidence Based Complementary and Alternative Medicine, pp. 1–16, 2011.

. T. Fushmen, H.G. Jeong, H.J. You, S.J. Park, A.R. Moon, Y.C. Chung, et al. “Hepatoprotective effects of 18β-glycyrrhetinic acids on carbon tetrachloride-induced liver injury, inhibition of cytochrome P450 2E1 expression”. Pharmacological Research, vol. 46(3), pp. 221–227, 2002.

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Published

2020-04-07

How to Cite

KGC, D. ., WMTDN, W. ., & WPRT, P. . (2020). Root/Stem Extracts of Glycyrrhiza glabra; As a Medicinal Plant Against Disease Forming Microorganisms. International Journal of Sciences: Basic and Applied Research (IJSBAR), 51(1), 1–11. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/11039

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Vol. 51 No. 1 (2020)

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