Sub-chronic Toxicity of Anti-ectoparasitic Formulation Comprising Cymbopogon Citrates Essential Oil and Jatropha Curcas Fixed Oil in Swiss Albino Mice

  • Biniam Endale Department of Anatomy, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, PO box 2888
  • Mekbeb Afework Department of Anatomy, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, PO box 2888
  • Asfaw Debella Traditional & modern medicine research directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia, PO box 1242
  • Wondwossen Ergetie Department of Pathology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, PO box
  • Solomon Mequanint Department of Pharmacology, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia, PO box
Keywords: Cymbopogon citratus, anti-ectoparasite, medicinal plants, Sub-chronic toxicity, histopathology

Abstract

Ectoparasites are found widely distributed in all agro-ecological zones of Ethiopia. The problems they cause can be alleviated through the use of traditional medicinal plants.  Cymbopogon citratus is one of the traditional herbs commonly used for such purpose.  This study was conducted to profile safety of the C. citratus based anti ectoparasitic formulation. The toxicity study had shown significant weight change in animal group that received 3.75% of the formulation. There were also significant changes in serum lipid profiles of treated group animals compared with the control. The level of uric acid in animals treated with 3.75% of the formulation showed significant increase compared with the control. Liver and kidney histopathology of both treatment group animals revealed few mononuclear leucocytic infiltrations.  The blood cell parameters and different biochemical findings had revealed no sign of toxicity. However; other measured parameters like the body weight, histological and some biochemical findings had shown both significant and insignificant sign of toxicities.  Therefore; it is important to consider the effect of the formulation in prolonged treatment on body weight, uric acid excretion and lipid metabolism.

Author Biography

Mekbeb Afework, Department of Anatomy, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, PO box 2888
Associate professor of Anatomy

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Published
2020-06-23
Section
Articles