The Protective Role of Black Seeds (Nigella sativa) on the Tissues of Liver and Kidney in Female Rabbits Treated with Green Lean Body Capsule
Keywords:
Nigella sativa, Black Seeds, Rabbit, Kidney, Liver and Green Lean Body Capsule.Abstract
The seeds of Nigella sativa (Ranunculaceae herbaceous plant), commonly known as black seed or black cumin, are used as herbal medicine all over the world for the treatment and prevention of a number of disease and conditions like asthma, diarrhea and dyslipidaemia. The present study was carried out to investigate the effects of Nigella sativa in protection of the liver and kidney tissues against pathological changes caused by green lean body capsule in female rabbits. Fifteen female rabbits were involved in this study and were divided randomly into three groups (5 rabbits in each group) and treated as following daily for 30 days: control group drenched with 1ml normal saline orally; T1 group: drenched with (4.2mg/kg) of green lean body capsule orally; T2 group: drenched with green lean body capsule (4.2mg/kg) in addition to black seed (28mg/kg) orally. The (T1) group which received green lean body capsule only revealed approximately dominant destruction of liver and kidney tissues. While, group (T2) which received green lean body capsule in addition to black seeds revealed very mild destruction as compared with T1. On conclusion it seems likely that black seeds provided an excellent protection to liver and kidney tissues against oxidative stress of green lean body capsule.
References
Dattner, A.M. (2003). From medical herbalism tophytotherapy in dermatology: back to the future. Dermatol Ther 16: 106
Huffman, M.A. (2003). Animal self-medication and ethno-medicine: exploration and exploitation of the medicinal properties of plants. Proc. Nutr. Soc., 62:371
Miller, K.L.; Liebowitz, R.S. and Newby, L.K. (2004). Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. Am. Heart J., 147: 401
Thatte, U.M.; Kulkarni, M.R. and Dahanukar, S.A. (1992). Immuno-therapeutic modification of Escherichia coli peritonitis and bac-teremia by Tinospora cordifolia. J. Postgrad. Med., 38: 13
Rege, N.N., Thatte, U.M., Dahanukar, S.A. (1999). Adaptogenic proper-ties of six rasayana herbs used in Ayurvedic medicine. Phytother. Res., 13: 275
Salem, M.L. and Hossain, M.S. (2000). Protective effect of black seed oil from Nigella sativa against murine cytomega lo virus infection. Int J Immunopharmacol Sep., 22(9):729
Goreja, W.G. (2003). Black Seed: Nature
Schleicher, P. and Saleh, M. (1998). Black seed cumin: the magical Egyptian herb for allergies, asthma, and immune disorders Healing Arts Press, Rochester, Vermont, p: 90.
Junemann, M. (1998). Three great healing herbs. Lotus Light Publications, silver lake., p: 45.
El-Dakhakhny, M. (1965). Studies on the Egyptian Nigella sativa L: IV. Some pharmacological properties of the seeds
Al-Rowais, N.A. (2002). Herbal medicine in the treatment of diabetes mellitus. Saudi Med J., 23: 1327
Morikawa, T.; Xu, F.; Kashima, Y.; Matsuda, H.; Ninomiya, K. and Yo shikawa , M. (2004). Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Org Lett., 6: 869
Morikawa, T., Xu, F.; Ninomiya, K.; Matsuda, H. and Yoshikawa, M. (2004). Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Chem. Pharm. Bull., 52: 494
Omar, A., Ghosheh, S.; Abdulghani, A.; Houdi, A. and Crookscor, P.A. (1999). High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in thof the black seed (Nigella sativa L). J. Pharm. Biomed. Anal., 19: 757
Al-Jassir, M.S. (1992). Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia. Food Chem., 45: 239
Chun, H.; Shin, D.H.; Hong, B.S.; Cho, W.D. and Yang, H.C. (2002). Biochemical properties of polysaccharides from black pep-per. Biol Pharm Bull., 25: 1203
Correa, A.D.; Jokl, L.R. and Carlsson, (1986). Amino acid composition of some Amaranthus sp. Grain proteins and of its fractions. Arch. Latinoam. Nutr.,36: 466
El-Mahmoudy, A., H.; Matsuyama, M.A.; Borgan, Y.; Shimizu, M.G.; El-Sayed, N. and Minamoto, (2002). Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol, 2: 1603
19.Luna, L.G. (1986). Manual of Histological Staining .method of armed forces institute of pathology.3rd ed.McGraw-Hill Book company.Newyork.
Harper, J. B. (2005). Biochemistry 2nd edition , London, New York Chapman and Hill :84
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