Polymorphism in the Melanocortin-4 Receptor (MC4R) Gene and its Effect on Fatness and Weight Performance of Philippine Native Pigs: A Preliminary Study
Keywords:
Asp298Asn, missense mutation, MC4R gene, Philippine Native Pig, RFLPAbstract
The single nucleotide substitution (Asp298Asn) in the melanocortin-4 receptor (MC4R) gene has been reported to be associated with several production traits in different swine breeds.
References
M.F. Rothschild. Advances in Pig Molecular Genetics. ITEA.96A: 349-361. 2000
K.S. Kim., N.J. Larsen and M.F. Rothschild. Rapid communication: Linkage and physical
mapping of the porcine melanocortin-4 receptor (MC4R) gene. Journal of Animal Scence. 78: 791-
2000.
R.,I. Davoli, S. Nissi, L. Braglia Fontanessi, L. Buttazzoni and V. Russo. Analysis of MC4R polymorphism in Italian Large White and Italian Duroc Pigs: Association with carcass traits. Meat Sci. 90(4): 887-892. 2012.
K.S. Kim , N.J. Larsen., T. Short, G. Plastow and M.F. Rothschild. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth and feed intake traits. Mammalian Genome. 11: 131-135. 2000.
K.S. Kim, J.M. Reecy, W.H. Hsu, L.L. Anderson and M.F. Rothschild. Functional and phy logenetic analyses of a melanocortin-4 receptor mutation in domestic pigs. Domestic Animal Endocrinology. [Pubmed]. 2004.
K. Salajpal, M. Dikic, J. Karolyi, M. Matkovic and B. Liker. Effect of MC4R polymorphism on physiological stress response in pigs. Poljoprivreda Osijek. 12: 2. 2007.
M. Chen, A. Wang, F. Fu, Jinlian and Ning, L. Different allele frequencies of MC4R gene variants in Chinese Pig Breeds. Arch. Tierz., Dummerstorf. 47 (5): 463-468. 2004.
R. Jokubka, S. Maak, S. Kerziene and H.H Swalve. Association of a melanocortin-4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. Journal of Animal Breeding and Genetics. 123: 17-22. 2006
C. Ovilo, A. Fernandez., M.C. Rodriguez., M. Nieto., L. Silio. Association of MC4R gene variants with growth fatness, carcass composition and meat and fat quality traits in heavy pigs. Meat Science. 73: 42-47. 2006.
C.L. Li, Y.C. Pan and H. Meng. Polymorphism of the H-FABP, MC4R and ADD1 genes in the Meishan and four other pig populations in China. South African Journal of Animal Science. 36: 1. 2006.
M. Szyndler-Nedza, M. Tyra, T. Blicharski and K. Piorkowska. Effect of mutation in MC4R gene on carcass quality in Pulawska pig included in conservation breeding programme. Animal Science Papers and Reports. (28).1: 37-45. 2010.
J.F. Chen, Y.Z. Xiong, B. Zuo, R. Zheng, F.E. Li, M.G. Lei, J.L. Li, C.Y. Deng and S.W. Jiang. New evidences of Effect of Melanocortin-4 Receptor and Insulin-like Growth Factor 2 Genes on Fat Deposition and Carcass Traits in Different Pig Populations. Asian-Australasian Journal of Animal Science. 18 (1): 1542-1547. 2005.
Y. Xiao-Hui, L. Yuan, T. Hui, Z. Ning-Bo, W. Ying, W. Shu-Dong and J. Yun-Lian. Polymorphism of MC4R Asp298Asn site and its relationship with backfat thickness in commercial pigs. Chinese Journal of Agricultural Biotechnology. 5 (3). 2008.
J.G. Roh, K. Sang-Wook, C. Jung-Suk, C. Yang-II, K. Jong-Joo, C. Bong-Hwan, T.H. Kim and K. Kwan-Suk. Characterization and Evaluation of Melanocortin 4 Receptor (MC4R) Gene Effect on Pork Quality Traits in Pigs. Journal of Animal Science and Technology. 54 (1). 2012.
M. Stachowiak, M. Szydlowski, M. Obarzanek-Fojt and M. Switonski. An effect of a
missense mutation in the porcine melanocortin-4 receptor (MC4R) gene on production traits in
Polish pig breeds is doubtful. Anim. Genet. [Pubmed]. 2006.
K. Salajpal, M. Dikic, D. Karolyi, Z. Janjecic and I. Juric. The effect of MC4R polymorphism on carcass composition and meat quality traits in pigs slaughtered at different live weights. Italian Journal of Animal Science. 8 (3): 98-100. 2009.
C.R. Schwab, B.E. Mote, Z.Q. Du, R. Amoako, T.J. Baas and M.F. Rothschild. An evaluation of four candidate genes for use in selection programmes aimed at increasing intramuscular fat in Duroc Swine. Journal of Animal Breeding and Genetics. 126: 228-236. 2009.
V. Dvorakova, R.M. Stupka, M. Sprysl, J. Citek, M. Okrouhla, E. Kluzakova and H. Kratochvilova. Effect of the missense mutation Asp298Asn in MC4R on growth and fatness traits in commercial pig crosses in the Czech Republic. Czech. Journal of Animal Science. 56 (4): 176-180. 2011.
I.K. Liyadskiy, A.A Getya and K.F. Pochernyaev. Association of the Asp298Asn polymorphism in the MC4R Gene with Backfat Thickness in Pigs of the Large White Breed. Cytology and Genetics. 45:2. 2011.
FFTC. Food and Fertilizer Technology Center. Utilization of Native Animals for Building Rural Enterprise in Warm Climate Zone. 25-27 pp. 2010.
R.D. Houston, N.D. Cameron and K.A Rance. A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected Large White Pig populations. Animal Genetics. 35 (5): 386-390. 2004.
B. Fan, S.K. Onteru, G.S. Plastow and M.F. Rothschild. Detailed characterization of the porcine MC4R gene in relation to fatness and growth. Animal Genetics. 40, 401-409. 2009.
P.J.A Bollen, L.W. Madsen, O. Meyer and J. Ritskes-Hoitinga. Growth differences of male and female Gottingen minipigs during ad libitum feeding: a pilot study. Laboratory Animals. 39:80. 2005.
M.E. McCann and E. Magowan. The evaluation of ultrasonic instruments used to measure the depth of back fat at P2 in live pigs: Agri-Food and Bio Sciences Institute. 2004.
C.P. McPhee and L.J. Daniels. Effects of genotype, diet and sex on backfat depth in pigs measured physically at different carcass sites and ultrasonically at different liveweight. Australasian Journal of Experimental Agriculture. 31: 761-4. 1991.
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