The Influence of Adjuvant Radiotherapy on Physical Symptoms and Quality of Life In IB1 Stage Cervical Cancer Patients

Authors

  • Ija Lisovaja
  • Jelena Rusakova
  • Ronalds Macuks

Keywords:

cervical cancer, quality of life, radiation therapy, hysterectomy

Abstract

Cervical cancer is the fourth most common cancer affecting women worldwide. Radical hysterectomy with pelvic lymphadenectomy with or without adjuvant radiation therapy is used as primary therapy for IB stage carcinoma of the cervix. The aim of this study was to compare the complications and quality of life of patients with stage IB1 cervical carcinoma treated by surgery or combined surgery and adjuvant radiotherapy. In a prospective case-control study 49 patients diagnosed with a cervical cancer were included - 37 patients receiving adjuvant radiotherapy in the study group and 12 patients without radiotherapy in the control group that were undergoing surgical treatment in Riga Eastern Clinical university hospital between January 2011 and December 2012.

Mean age was higher in patients who received adjuvant radiotherapy in comparison to patients who received only surgical treatment

References

Ferlay J., Soerjomataram I., Ervik M., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 Lyon, France: International Agency for Research on Cancer, GLOBOCAN 2012 v1.0, 2013.

Finan M.A., Abdoh A.A., Fiorica J.V., Hoffman M.S., Roberts W.S., Cavanagh D. Radical hysterectomy for stage IB cervical cancer: recurrence intervals a predictor of survival. Southern medical journal, N 6, vol.86, p. 591- 596, 1996.

Perez C.A., Breaux S., Madoc-Jones H., Bedwinek J., Camel M. et al. Radiation Therapy Alone in the Treatment of Carcinoma of Uterine Cervix. Cancer, N 8, vol.51, p.1393- 1402, 1983.

Frumovitz M., Sun C. C., Schover L. R., Munsell M.F., Jhingran A., Wharton J.T. et al. Quality of Life and Sexual Functioning in Cervical Cancer Survivors. Journal of Clinical Oncology, N 30, vol.23, p. 7428-7436, 2005.

Kundargi R.S., Guruprasad B., Rathod P.S., Shakuntala P.N., Shobha K., Pallavi V.R., Devi K.U., Bafna U.D. Risk strata-based therapy and outcome in stage Ib

Berza N., Vitols J., Reinis A., Skadins I., Macuks R. The influence of adjuvant radiotherapy on ovarian function, menopausal symptoms and quality of sexual life in cervical cancer patients. International Journal of Collaborative Research on Internal Medicine& Public Health, N 6, vol.5, p. 377- 385, 2013.

Maduroa J.H., Prasa E., Willemseb P.H.B., deVries E.G.E. Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer. Cancer Treatment Reviews, N 6, vol.29, p. 471- 488, 2003.

Bergmark K.,

Classen J., Belka C., Paulsen F., et al. Radiation-induced gastrointestinal toxicity. Pathophysiology, approaches to treatment and prophylaxis. Strahlenther Onkologie, N 174, p. 82-84, 1998.

Zelefsky M.J., Cowen D., Fuks Z., Shike M., Burman C., Jackson A., Venkatramen E.S., Leibel S.A. Long term tolerance of high dose three-dimensional conformal radiotherapy in patients with localized prostate carcinoma. Cancer, N 11, vol.85, p. 2460- 2468, 1999.

Peeters S.T.H., Heemsbergen W.D., van Putten W.L.J., Slot A., Tabak H., Mens J.W., Lebesque J.L., Koper P.C.M. Acute and late complications after radiotherapy for prostate cancer: Results of a multicenter randomized trial comparing 68 Gy to 78 Gy. International Journal of Radiation Oncology, N 4, vol.61, p. 1019

Andreyev J. Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients. The Lancet Oncology, N 11, vol.8, p. 1007

Hsu W.C., Chung N.N., Chen Y.C., Ting L.L., Wang P.M., Hsieh P.C., Chan S.C. Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer. Gynecologic Oncology, N 115, p. 41

Stewart F.A. Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs. British Journal of Cancer, N 7, p. 280- 291, 1986.

Abu-Rustuma N.R., Alektiarb K., Iasonosc A., Leva G., Sonoda Y., Aghajaniand C., Chia D.S., Barakata R.R. The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: A 12-year experience at Memorial Sloan-Kettering Cancer Center. Gynecologic Oncology, N 2, vol.103, p. 714

Colombo N., Carinelli S., Colombo A., Marini C., Rollo D., Sessa C. Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, N 7, vol.23, p. vii27- vii32, 2012.

Rotman M., Sedlis A., Piedmonte M.R., M.A., Bundy B., Lentz S.S., Muderspach L.I., Zaino R.J. A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features: Follow-up of a gynecologic oncology group study. International journal of radiation oncology, biology, physics, N 1,vol.65, p. 169

NCCN Clinical Practice guidlines in Oncology. Cervical Cancer, 2009.

Okazawa M., Matsuo K., Mabuchi S., Matsumoto Y., Tsutsui T., Fujita M., Kamiura S., Ogawa K., Morrow C.P., Kimura T. Utility of risk-weighted surgical-pathological factors in early-stage cervical cancer. British journal of cancer, N 6, vol.108, p. 1348- 1357, 2013.

Beesley V., Janda M., Eakin E., Obermair A., Battistutta D. Lymphedema After Gynecological Cancer Treatment; Prevalence, Correlates, and Supportive Care Needs. Cancer, 2007, N 12, vol.109, p. 2607- 2614.

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Published

2014-05-19

How to Cite

Lisovaja, I., Rusakova, J., & Macuks, R. (2014). The Influence of Adjuvant Radiotherapy on Physical Symptoms and Quality of Life In IB1 Stage Cervical Cancer Patients. International Journal of Sciences: Basic and Applied Research (IJSBAR), 15(1), 699–707. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/2253

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