Weight Gain and Blood Glucose Level in Granting Trans Fatty Acids (Study at Sprague Dawley)
Keywords:
ALT, Weight, Blood Glucose.Abstract
Obesity was often cause by excessive food intake, lack of physical activities, genetic susceptibility, endocrine disorders, psychiatry disease. Pathogenesis DM type 2 was disturbance insulin or lack of insulin which result of genetic factor interaction, environment and life style changes. The life style changes were increasing the intake of fast foods, snack foods hydrogenated, the amount of consumption of fried foods, which turned out to contain trans fatty acids, causing obesity and diabetes mellitus type 2. How interaction with weight gain and level of blood glucose was unclearly. The result of study was analyzing effect of ALT against to weight gain and level of blood glucose. The study was experimental with randomized controlled group pretest posttest design, conducted at LPPT Unit IV UGM Yogyakarta. The sample was 30 male Sprague Dawley rat and aged 8 weeks, weight 200-300 grams and divided into 3 groups , were control group, group of Treatment I with ALT granting 5% and group of Treatment II with ALT granting 10% during 8 weeks, and weight and level of blood glucose checked. The parameter difference before and after the intervention was analyzed with Wilcoxon testing. ALT granting 5% and 10% during 8 weeks increase weight and blood glucose level significantly. In conclusion, the high dose of ALT increases weight and blood glucose.
References
Barness LA, Opitz JM, Gilbert-Barness E 2007. "Obesity: genetic, molecular, and environmental aspects". Am. J. Med. Genet. A143A (24): 3016
Haslam DW, James WP (2005). "Obesity". Lancet366 (9492): 1197
Poulain M, Doucet M, Major GC et al. (April 2006). "The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies". CMAJ174 (9): 1293
Anna LK . "Indonesia Masuk 10 Besar Orang Gemuk Terbanyak" Kompas Juni 2014
Lithell HO, Mc Keigue PM, Berglund L, Mohsen R, Lithell U, Ledon DA. Relation of soze at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ. 1996;312:406-10
Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker DJP. Early adiposity in childhood and risk of tyoe 2 diabetes in adult life. Diabetologia. 2003;46:190-94
Bouwens L. & Rooman I. 2005. Regulation of Pancreatic Beta-Cell Mass. American Physiological Society, 854, 1255-70.
Aronson D. Hyperglycemia and the pathobiology of diabetic complications. AdvCardiol 2008;45:1-16.
Perkeni, Konsensus Pengelolaan DM Tipe 2 di Indonesia, 2006.
Arslanian SA.Type 2 diabetes mellitus in children: pathophysiology and risk factors.J Pediatr Endocrinol Metab.2000;13 Suppl 6:1385-94.
Tuomilehto J., Lindstr
Krishnan S, Coogan PF, Boggs DA, Rosenberg L, Palmer JR. Consumption of restaurant foods and incidence of type 2 diabetes in African American women.Am J Clin Nutr. 2010;91:465-71.
Tjokroprawiro A. 2008. The Obesity Pandemic: The
Mayes PA. Biosintesis asam lemak. In; Murray RK, Granner DK, Mayes PA, Rodwell VW, editors. Biokimia 25 ed. Jakarta; Penerbit EGC Kedokteran; 2003. p. 27-8
Zock PL, Katan MB. Hydrogenation alternatives: Effect of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. J Lipid Res. 1992;33;30:399-410
Baer DJ. What do we really know about the health effects of natural sources of trans fatty acids? Am J Clin Nutr2012;95:267-8.
Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, et al. Diet and lifestyle recommendations revision 2006; a scientific statement from the American heart Association Nutrition Committee. Circulation. 2006;114(1):82-96.
Anonymus 2008. Evidence to Action, International Diabetes Federation Western Pasific Regional.doi:10.1002/ajmg.a.32035. PMID 18000969.
Yamada M, Sasaki S, Murakami K, Takahashi Y, Uenishi K. Association of trans fatty acid intake with metabolic risk factors among free-living young Japanese women.Japan Dietetic Students' Study for Nutrition and Biomarkers Group.Asia Pac J Clin Nutr. 2009;18(3):359-71.
Gallagher EJ, Roith D, Bloomgarden Z.Review of hemoglobin A1C in the managementof diabetes. Journal of Diabetes 1.2009; 9-17.
Huang Z, Wang B, Pace RD, Yoon S, et al. Trans fat intake lowers total cholesterol and high-density lipoprotein cholesterol levels without changing insulin sensitivity index in Wistar rats. Departemen of Food and Nutritional Sciences, Tuskegee University. Elsevier. Science Direct. Nutrition Research.2009; 29:206-12.
Kavanagh K., Jones KL, Sawyer J, Kelley K, CarrJJ, Wagner JD, et al. Trans Fat Diet Induces Abdominal Obesity and Changes in Insulin Sensitivity in Monkeys. Obesity (2007) 15,1675-84;doi:10.1038/oby.2007:200.
Dorfman SE, Laurent D, Gounarides JS, Li Xue, Mullarkey TL, Rocheford EC. Metabolic Implication of Dietary Trans-fatty Acids. Obesity journal org.2009;17(6):1200-7.
Urakawa H. 2003. Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men. The Journal of Clinical Endocrinology & Metabolism, 10(88), 4673-6.
Malhi H, Gores GJ. 2008. Molecular Mechanism of Lipotoxicity in Fatty Liver Disease. Semin Liver Dis., 28(4):360-9.
Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, Stamfer MJ, et al. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J nutr 135,2005;135:562-6
Garrison RR. Normal Rat Blood Glucose Level.http://www.ehow.com/facts_5990203_normal-rat-blood glucose-level.html. 2012, Dimand Media,Inc.
Muller H, Lindman AS, Blomfeldt A, Seljeflot I. Pedersen JI. A Diet Rich in Coconut Oil Reduces Diurnal Postprandial Variations in Circulating Tissue Plasminogen Activator Antigen and Fasting Lipoprotein (a) Compared with a Diet Rich In UnSaturated Fat in Women. Human Nutrition & Metabolism.J Nutr. 2003;133: 3422-7.
Riserus U. Trans fatty acids, insulin sensitivity and type 2 diabetes. Scandinavian Journal of Food and Nutrition. 2006;50(4):161-5.
Koppel AWP, Elias M, Moseley RH, Green RM. Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. AJP-GI;2009;297; 2: G378-84.
Dubois M. Glucotoxicity inhibit late step of insulin of insulin exoccitosis. Endocrinology 2007:148:148:1606-14.
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