Comparing Cd4 Counts in Syphilitic and Non Syphilitic HIV Patients, Luwero District Uganda

Authors

  • Sadala Cassim Mbarara University of Science and Technology, P. O Box 1410, Mbarara Uganda
  • Enoch Muwanguzi Mbarara University of Science and Technology, P. O Box 1410, Mbarara Uganda
  • Richard Apecu Onyuthi Mbarara University of Science and Technology, P. O Box 1410, Mbarara Uganda
  • Caesar Oyet International Health Sciences University, P. O Box 7782, Kampala Uganda

Keywords:

HIV, syphilis, CD4, HAART naïve, coinfection.

Abstract

Close to 12 million people living with Human Immunodeficiency Virus (HIV) infection were infected with syphilis in 2004. Most of these infections occurred in developing countries with sub-Saharan Africa and South East Asia dominating. The global efforts to tackle syphilis infection are mostly aimed at pregnant women yet such kind of localized interventions leave other susceptible individuals at risk of infection leaving great public and clinical impact.

The aim of our study was to compare CD4 counts in HIV positive syphilis negative and syphilis positive Highly Active Antiretroviral therapy (HAART) na

References

M. E. Patton, et al., "Primary and secondary syphilis--United States, 2005-2013," MMWR. Morbidity and Mortality Weekly Report, vol. 63, pp. 402-6, May 9 2014.

CDC, "Morbidity and Mortality Weekly Report (MMWR): Primary and Secondary Syphilis

M. Endris, et al., "Seroprevalence of syphilis and human immunodeficiency virus infections among pregnant women who attend the University of Gondar teaching hospital, Northwest Ethiopia: a cross sectional study," BMC Infect Dis, vol. 15, p. 111, 2015.

A. A. Moura, et al., "Prevalence of syphilis, human immunodeficiency virus, hepatitis B virus, and human T-lymphotropic virus infections and coinfections during prenatal screening in an urban Northeastern Brazilian population," International Journal of Infectious Diseases, vol. 39, pp. 10-5, Oct 2015.

S. Dougan, et al., "Sexually transmitted infections in Western Europe among HIV-positive men who have sex with men," Sexually Transmitted Diseases, vol. 34, pp. 783-90, Oct 2007.

M. Melku, et al., "Magnitude of HIV and syphilis seroprevalence among pregnant women in Gondar, Northwest Ethiopia: a cross-sectional study," HIV AIDS (Auckl), vol. 7, pp. 175-82, 2015.

S. E. Msuya, et al., "Prevalence of sexually transmitted infections among pregnant women with known HIV status in northern Tanzania," Reprod Health, vol. 6, p. 4, 2009.

S. C. Kalichman, et al., "Prevalence of Sexually Transmitted Co-Infections in People Living with HIV/AIDS: Systematic Review with Implications for using HIV Treatments for Prevention," Sexually Transmitted Infections, vol. 87, pp. 183-90, Apr 2011.

W. A. Lynn and S. Lightman, "Syphilis and HIV: a dangerous combination," Lancet Infect Dis, vol. 4, pp. 456-66, Jul 2004.

WHO, "The global elimination of syphilis: rationale and strategy for action. Geneva, Switzerland: World Health Organization; 2007.," 2007.

O. A. Aydin, et al., "Seroprevalence and risk factors of syphilis among HIV/AIDS patients in Istanbul, Turkey," Central European Journal of Public Health, vol. 23, pp. 65-8, Mar 2015.

S. Kukanok and S. Kiertiburanakul, "Prevalence of positive syphilis serology among HIV-infected patients: role for routine screening in Thailand," Southeast Asian Journal of Tropical Medicine and Public Health, vol. 45, pp. 435-41, Mar 2014.

L. Lopes, et al., "[Syphilis: Prevalence in a Hospital in Lisbon]," Acta Medica Portuguesa, vol. 29, pp. 52-5, Jan 2016.

E. J. Kim, et al., "Sexually transmitted infections associated with alcohol use and HIV infection among men who have sex with men in Kampala, Uganda," Sexually Transmitted Infections, Sep 30 2015.

M. O. Osinde, et al., "Sexually transmitted infections in HIV-infected patients in Kabale Hospital, Uganda," J Infect Dev Ctries, vol. 6, pp. 276-82, Mar 2012.

Y. C. Manabe, et al., "Integration of antenatal syphilis screening in an urban HIV clinic: a feasibility study," BMC Infect Dis, vol. 15, 2015.

G. W. Rutherford, et al., "University students and the risk of HIV and other sexually transmitted infections in Uganda: the Crane survey," Int J Adolesc Med Health, vol. 26, pp. 209-15, 2014.

T. Shimelis, et al., "Syphilis among people with HIV infection in southern Ethiopia: sero-prevalence and risk factors," BMC Infect Dis, vol. 15, 2015.

O. Kotsafti, et al., "Early syphilis affects markers of HIV infection," International Journal of STD and AIDS, Jun 24 2015.

A. Ganesan, et al., "Results of a 25-year longitudinal analysis of the serologic incidence of syphilis in a cohort of HIV-infected patients with unrestricted access to care," Sexually Transmitted Diseases, vol. 39, pp. 440-8, Jun 2012.

C. R. Pearson, et al., "Modeling HIV transmission risk among Mozambicans prior to their initiating highly active antiretroviral therapy," AIDS Care, vol. 19, pp. 594-604, May 2007.

B. Tessema, et al., "Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years," BMC Infect Dis, vol. 10, p. 111, 2010.

V. Spagnuolo, et al., "Predictors of lack of serological response to syphilis treatment in HIV-infected subjects," J Int AIDS Soc, vol. 17, p. 19654, 2014.

R. Palacios, et al., "Impact of syphilis infection on HIV viral load and CD4 cell counts in HIV-infected patients," Journal of Acquired Immune Deficiency Syndromes, vol. 44, pp. 356-9, Mar 1 2007.

W. Jarzebowski, et al., "Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort," Archives of Internal Medicine, vol. 172, pp. 1237-43, Sep 10 2012.

K. Buchacz, et al., "Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections," AIDS, vol. 18, pp. 2075-9, Oct 21 2004.

K. Kofoed, et al., "Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response," Sexually Transmitted Diseases, vol. 33, pp. 143-8, Mar 2006.

J. N. Jarvis, et al., "Is HIV-associated tuberculosis a risk factor for development of cryptococcal disease?," AIDS, vol. 24, pp. 612-4, Feb 20 2010.

J. L. Castilho, et al., "CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy," AIDS, vol. 30, pp. 899-908, Mar 27 2016.

F. Caby, et al., "Determinants of a Low CD4/CD8 Ratio in HIV-1-Infected Individuals Despite Long-term Viral Suppression," Clinical Infectious Diseases, vol. 62, pp. 1297-303, May 15 2016.

M. T. May, et al., "Mortality according to CD4 count at start of combination antiretroviral therapy among HIV positive patients followed for up to 15 years after start of treatment: collaborative cohort study," Clinical Infectious Diseases, Mar 29 2016.

Downloads

Published

2017-01-25

How to Cite

Cassim, S., Muwanguzi, E., Onyuthi, R. A., & Oyet, C. (2017). Comparing Cd4 Counts in Syphilitic and Non Syphilitic HIV Patients, Luwero District Uganda. International Journal of Sciences: Basic and Applied Research (IJSBAR), 31(2), 21–27. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/5597

Issue

Section

Articles