Serum and Salivary Markers in Aggressive Periodontitis Patients In Mosul
Keywords:
Aggressive Periodontitis, Serum and Salivary Markers.Abstract
This study also showed direct correlation between serum IL-1? and Salivary peroxidase, also between (IgA, total protein and peroxidase Specific activity in saliva). Finally presence of direct correlation between peroxidase specific activity and total protein.
The aims of the study is to assess and compare serum levels of cytokines (IL-8,IL-6,IL-1?,IFN-? and TNF-?) and salivary markers (sIgA, peroxidase, peroxidase specific activity and total protein) in aggressive periodontitis patients and periodontally healthy individuals in Mosul. This study was carried out on a total number of 49 subjects, 24 Aggressive Periodontitis patients,14 males and 10 females, aging between 20 - ?40 years, and 25 healthy subjects as control group which consisted of 14 males and 11 females aging between 20-45 years. All patients were systemically healthy. Five ml of venous blood and saliva were withdrawn from each patient and control subject, for assessments of serum cytokines (IL-8,IL-6,IL-1?,IFN-? and TNF-? ) and salivary markers (sIgA, total protein and peroxidase specific activity) using
References
Demmer RT. and Papapanou PN. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000, 2010;53:28-44.
Armitage GC. Periodontal diagnosis and classification of periodontal disease. Periodontol 2000, 2004;34:9-22.
Albandar JM. Aggressive periodontitis: case definition and diagnostic criteria. Periodontol 2000, 2014; 65(1): 13
Masamatti SS, Kumar A, Baron TA, Mehta DS and Bhat K. Evaluation of interleukin -1B (+3954) gene polymorphism in patients with chronic and aggressive periodontitis: A genetic association study. Contempt Clin Dent, 2012; 3(2):144-9
Erciyas K, Pehlivan S, Sever T, Igci M, Arslan A. and Orbak R. (2010) Association between TNF-?, TGF-?1, IL-10, IL-6 and IFN-? gene polymorphisms and generalized aggressive periodontitis. Clin Invest Med, 2010;33 (2): E85-E91.
Joshipura V, Yadalam U. and Brahmavar B. Aggressive periodontitis: A review. J Int Clin Dent Res, 2015;7 (1):11-17
Ranney R. Classification of Periodontal Diseases. Periodontol 2000, 1993;2:13.
Susin C, Haas AN and Albandar JM. Epidemiology and demographics of aggressive periodontitis. Periodontol 2000, 2014;65:27-45.
Chahboun H, Arnau MM, Herrera D, Sanz M and Ennibi OK. Bacterial profile of aggressive periodontitis in Morocco: a cross-sectional study . BMC Oral Health, 2015;15:25.
Armitage GC and Cullinan MP. Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol 2000, 2010;53(1):12
Schacher B, Baron F, Rossberg M, Wohlfeil M, Arndt R and Eickholz P. Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies. J Clin Periodontol, 2007;34:566
Champagne CM, Buchanan W, Reddy MS, Preisser JS, Beck J and Offenbacher S. Potential for gingival crevice fluid measures as predictors of risk for periodontal diseases. Periodontol 2000, 2003;31:167-80.
Newman MG, Takei HH, Carranza FA. Carranza's clinical periodontology- 9th ed. W.B. Saunders Co. 2002, pp: 409- 413.
Abbas AK and Andrew HL. Cellular and molecular immunology. 5th ed. University of Virginia, Elsevier 2007; 261-267.
Armitage G. Development of a classification system for periodontal diseases and conditions. Ann periodontal, 1999; 4:1-6.
Al-Shahat MA, Abd Al-Samad AA and Abd El-Aal IA. Aggressive and Slowly-Progressive Periodontitis in Patients with Coronary Artery Diseases. Levels of C-Reactive Protein, Fibrinogen, and IL-6. Cairo Dent J, 2008;24 (I):141-153.
Kejriwal S, Bhandary R, Thomas B and Kumari S. Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients, J Clin Diag Res, 2014;8(10): 56
Taha MYM and Al-Taei AM. Bacteriological and immunological study of aggressive periodontitis in Mosul. Al-Rafidain Dent J, special issue of the 5th Conference of Dentistry, 2011; 207-214
Guzeldmir E, Gunhan M, Ozcelik O, and Tastan H. Interleukin and tumor necrosis factor-? gene polymorphisms in Turkish patients with localized aggressive periodontitis. J Oral Sci, 2008;50(2): 151-159.
Rashmi H, Suchetha A, Apoorva SM , Bharwani AG and Karthik V. Estimation of Tumor Necrosis Factor-Alpha Levels in Gingival Crevicular Fluid In Periodontal Health and Disease In An Indian Population. Int. J Contempt Dent. (IJCD), 2011;2(6):23-29.
Duarte PM, da Rocha M, Sampaio E, Mestnik MJ, Feres M, Figueiredo LC, Bastos MF. and Faveri M. Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol, 2010.; 81(7):1056-63.
Martu I, Goriuc A, Luchian I, Holban CC, Macovei AS, Tatarciuc M, Balan A, Martu S. The Quantification of TNF- ? As A Marker in the Assessment of the Chronic and Aggressive Periodontal Pathology. Rom J Oral Rehab, 2014; 6(4) :92-98.
Kobayashi T and Yoshie H. Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis, Cur Oral Health Rep, 2015; 2:1
S?otwi?ska SM. Cytokines and periodontitis. Part II: tumor necrosis factor and soluble tumor necrosis factor receptor. Centr Eur J Immunol, 2012;37 (2):178-181.
Vahabi S, Sattari M, Taheraslani M, Bagheban AA. Correlation between Interleukin-1?, Interleukin-6 and Tumor Necrosis Factor-? and Clinical Parameters in Chronic and Aggressive Periodontal Disease. Journal of Periodontology & Implant Dentistry. J Periodontol Implant Dent; 2011;3(2):51
D
Feng J, Aboyoussef H, Weiner S, Singh S and Jandinski J. The effect of gingival retraction procedures on periodontal indices and crevicular fluid cytokine levels: a pilot study. J Prosthodont, 2006;15:108
Brett PM, Zygogianni P, Griffiths GS, Tomaz M, Parkar M, D
Noh MK, Jung M, Kim SH, Lee SR, Park KH, Kim DH, Kim HH and Park YG.(2013) Assessment of IL 6, IL 8 and TNF ? levels in the gingival tissue of patients with periodontitis. Exp Therap Med, 2013;6(3): 847-851.
Brocker C, Thompson D, Matsumoto A, Nebert DW and Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum Genomics, 2010;5:30-55.
Goutoundi P, Diza E. and Arvanitidou M. Effect of periodontal therapy on crevicular fluid interleukin-6 and interleukin-8 levels in chronic periodontitis. Int J Dent, 2011[Abstract]
Haq MW, Tanwir F, Tabassum S, Nawaz M and Siddiqui MF. Association of Periodontitis and Systemic Diseases Int J Dent Oral Health, 2015;1(1): 1-7.
Tatakis DN. Interleukin-1 and bone metabolism: A review. J Periodontol, 1993; 64:416-31.
[ 34] Stefanovska E, Nakova M, Ivanovski K. and Popovska M. Interleukin-1 (ILI-? and ILl-?) in gingival fluid and serum of patients with gingivitis and periodontitis, Balkan J of Stomatol, 2012;16(1): 34-38.
de Lima Oliveira AP, de Faveri M, Gursky LC, Mestnik MJ, Feres M, Haffajee AD, Socransky SS. and Teles RP. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol, 2012;39(3):295-302.
Gurban CV, and Drugarin D. Immune-inflammatory markers in the periodontal disease. Eur Cells Mat, 2008;16(5): 22.
Mattuella LG, Campagnaro MB, Vargas AE, Xavier LL, Oppermann RV, Chies JAB and Miranda LA. Plasma cytokines levels in aggressive and chronic periodontitis. Acta Odontol Scand, 2013;71( 3-4): 683-688.
Mirza KB and Al-Azzawi LM. Peroxidase enzyme activity in gingival tissues associated with aggressive periodontitis: Histochemical investigation. Med J Babylon, 2008; 5(2): 168-175.
Gomes DA, Pires JR, Zuza EP, Muscara MN, Herrera BS, Spolidorio LC, Toledo BE, and Spolidorio DM, Myloperoxidase as inflammatory marker of periodontal disease: Experimental study in rats. Immunol Invest, 2009;38(2): 117-122.
Sax
Daniel FH. Localized Aggressive Periodontitis: Microbial &Host Markers for Susceptibility. National institutes of health, 2011, [abstract].www.nih.gov.
Al-Rassam ZT and Taha MYM. Serum Cytokines Profiles and Some Salivary Parameters in Chronic Periodontitis Patients in Mosul - Iraq . Int J Sci Basic Appl Res (IJSBAR), 2014;16 ( 1) :339-350.
S
Pai MGP and Shetty P. Salivary protein concentration, flow rate, buffering capacity and pH estimation: A comparative study among young and elderly subjects, both normal and with gingivitis and periodontitis. J Indian Soc Periodontol, 2013;17(1):42
Guentsch A, Hiese I, Puklo M, Kiehntopf M, Pfister W, and Eick S. Variables of host response in saliva of patients with periodontitis: a pilot study. Quintessence Int, 2012;43:104-114.
Rocha D, Zen
Henskens YM, Van Der Velden U, Veerman EC. and Amerongen NAV. Protein, albumin and cystatin concentrations in saliva of healthy subjects and of patients with gingivitis or periodontitis. J Periodontal Res, 1993;28(1):43
Panchbhai AS, Degwekar SS and Bhowte RR. Estimation of salivary glucose, salivary amylase, salivary total protein and salivary flow rate in diabetics in India. J Oral Sci, 2010;52(3):359
Yue Y, Liu Q, Xu C, Loo WTY, Wang M, Wen G, Cheung MNB, Bai L, Dou Y, Chow LWC, Hao L, Tian Y, Li J, Yip AYS. and Ng ELY. Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis . Int J Biol Markers,2013;28(1):108 - 112 .
Downloads
Published
How to Cite
Issue
Section
License
Authors who submit papers with this journal agree to the following terms.
