The Ability of Namnam (Cynometra cauliflora) Leafs Extract as Antidiabetic Agent Through ?
Keywords:
?-glucosidase, Antidiabetic, Cynometra cauliflora, Extraction, Namnam .Abstract
The prevalence of patients with Diabetes Mellitus (DM) is increasing dramatically worldwide. One therapeutic approach to treat diabetes by inhibiting the absorption of glucose through inhibiting ?-glucosidase. Plant that is potential for this benefit is namnam (Cynometra cauliflora). ?-glucosidase inhibitory activity of namnam leafs extract (Cynometra cauliflora) can be tested at various stages of extraction such as maceration with methanol, liquids extraction (solvent: n-hexane, ethyl acetate and n-butanol), and column chromatography. ?-glucosidase inhibitory activity was tested in vitro using a p-nitrophenyl- ?-D-glucopyranoside (PNPG) as a substrate.
The analysis showed that the IC50 value at maceration stage with methanol is 5.58
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