Human Leucocyte Antigens (DRB1*03, DRB1*04 and DQB1*02) Associated with Type 1 Diabetes Mellitus Among 269 Kidney Graft Donors and Recipients in Kenya

Authors

  • Dr. Samuel K. Kabinga Maralal county referral hospital, P.O. Box 18882-00100 Nairobi.
  • Dr. Anthony Jude O. Consultant Physician/Nephrologist. Senior lecturer University of Nairobi, College of Health Sciences, School of Medicine, Department of Internal Medicine and Therapeutics. P.O. Box 30197-00100, Nairobi.
  • Prof. Kirana M. Bhatt Consultant Physician/Nephrologist. Senior lecturer University of Nairobi, College of Health Sciences, School of Medicine, Department of Internal Medicine and Therapeutics. P.O. Box 30197-00100, Nairobi.
  • Prof. Joshua K. Kayima Consultant Physician/Nephrologist. Senior lecturer University of Nairobi, College of Health Sciences, School of Medicine, Department of Internal Medicine and Therapeutics. P.O. Box 30197-00100, Nairobi.
  • Prof. Seth O. McLigeyo Consultant Physician/Nephrologist. Senior lecturer University of Nairobi, College of Health Sciences, School of Medicine, Department of Internal Medicine and Therapeutics. P.O. Box 30197-00100, Nairobi.

Keywords:

Type 1 diabetes mellitus, Human leucocyte antigens.

Abstract

This was a descriptive study which utilized the medical records for the kidney donors and recipients who had been followed up in the kidney transplantation programme in Kenyatta National Hospital, Nairobi, Kenya. Tissue typing is rarely performed routinely among our patients partially due to cost. It is with this in mind that we engaged in extraction of more information from the tissue typing data which have been used in kidney transplantation programme in Kenyatta National Hospital, Nairobi Kenya.

References

Longo, D.L., et al., Harrison's Principles of Internal Medicine. 18 ed. Vol. 1. 2012: The McGraw-Hill Companies.

Noble, J.A. and A.M. Valdes, Genetics of the HLA Region in the Prediction of Type 1 Diabetes. Curr Diab Rep, 2011. 11(6): p. 533

Guarene, M., et al., Targeting the Immunogenetic Diseases with the Appropriate HLA Molecular Typing: Critical Appraisal on 2666 Patients Typed in One Single Centre. BioMed Research International, 2013.

Howson, J.M.M., et al., HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype. Diabet. Med, 2013. 30: p. 710 -716.

Famuyiwa, O.O., I.E. Nwabuebo, and A.A. Abioye, Pattern of Histocompatibility (HLA) Antigen Distribution Among Nigerian (West African Black) Diabetics. Diabetes, 1982. 31: p. 1119-1122.

Howson, J.M.M., et al., HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype. Diabet Med, 2013. 30: p. 710-716.

Mohyuddin, A., et al., HLA polymorphism in six ethnic groups from Pakistan Tissue Antigens, 2002. 59(6): p. 492-501.

Lawlor, D.A., et al., Prevalence of diabetes in Pakistan. Diabetes Res Clin Pract, 2007. 76(2): p. 219-222.

Renquin, J., et al., HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity. Tissue Antigens, 2001. 58: p. 211-222.

Fort, M., et al., HLA class II allele and haplotype frequencies in Ethiopian Amhara and Oromo populations. Tissue Antigens, 1998. 51: p. 327-336.

Casado, E.G., et al., HLA genes in Arabic-speaking Moroccans: close relatedness to Berbers and Iberians. Tissue Antigens, 2000. 55: p. 239-249.

Fokianos, K., I. Sarrou, and I. Pashalidis, Increased radiation exposure by granite used as natural tiling rock in Cypriot houses. Radiation Measurements, 2007. 42(3): p. 446-448.

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Published

2016-09-27

How to Cite

K. Kabinga, D. S., Jude O., D. A., M. Bhatt, P. K., K. Kayima, P. J., & O. McLigeyo, P. S. (2016). Human Leucocyte Antigens (DRB1*03, DRB1*04 and DQB1*02) Associated with Type 1 Diabetes Mellitus Among 269 Kidney Graft Donors and Recipients in Kenya. International Journal of Sciences: Basic and Applied Research (IJSBAR), 30(1), 57–63. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/6335

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