Potency of Jack Fruit Leaves as Tyrosinase Inhibitor

Authors

  • Raendi Rayendra Medical Faculty and healthy science of Islamic State University Jakarta
  • Ietje Wientarsih Department of Pharmacy, Faculty of Veterinary, Bogor Agricultural University
  • Bambang P. Priosoeryanto Department of Pathology, Faculty of veterinary, Bogor Agricultural University
  • Hendra Gunawan Department of Dermato-Venereology, Medical Faculty of Padjadjaran University

Keywords:

Jack fruit leaves, phytochemistry, tyrosinase inhibitor.

Abstract

The aim of this study is to screen whitening agent potency from Jack fruit leaves compared between 96% ethanol extract from young Jack fruit leaves (green to white) and mature Jack fruit leaves (dark green). The phytochemistry examination showed that there was a strong indication of flavonoid in young Jack fruit leaves in 96% ethanol extract. The methods for screening as whitening agent is based on tyrosinase inhibitor potency using mushroom tyrosinase and the result of the young Jack fruit leaves in 96% ethanol extract are the most potent as tyrosinase inhibitor (monophenolase 29,9

References

Alison FS, Mary PL. 2009. Practical uses of Botanicals in Skin Care. J Clin Aesthetic Dermatology. 2(1): 36-40.

Solano F, Briganti S, Picardo M, Ghanem G. 2006. Hypopigmenting Agents: An Updated Review on Biological, Chemical and Clinical Aspects. Pigment Cell Res. 90: 550-571.

Khan M.R, A.D. Omoloso, M. Kihara. 1996. Antibacterial Activity of Artocarpus heterophyllus. Fitoterapia. 74: 501-505.

Arung ET, Muladi S, Sukaton E, Shimizu K, Kondo R. 2008. Artocarpin, A Promising Compound as Whitening Agent and Anti-skin Cancer. J Trop Wood Science and Technology. 6(1): 33-36.

Prakash OM, Kumar R, Mishra A, Gupta R. 2009. Artocarpus heterophyllus (Jackfruit): An Overview. Phcog Rev. 3(6): 353-358.

Arung ET, Shimizu K, Kondo R. 2006a. Inhibitory Effect of Isoprenoid-Substituted Flavonoids Isolated from Artocarpus heterophyllus on Melanin Biosynthesis. Planta Medica. 72: 847-850.

Arung ET, Shimizu K, Kondo R. 2006. Inhibitory Effect of Artocarpanone from Artocarpus heterophyllus on Melanin Biosynthesis. Biol. Pharm. Bulletin. 29(9): 1966-1969.

Picardo M, Carrera M. 2007. New and Experimental Treatments of Chloasma and other Hypermelanoses. Dermatol Clin. 25: 353-362.

Kim Y.J, Uyama H. 2005. Tyrosinase Inhibitors from Natural and Synthetic Sources: Structure, Inhibition Mechanism and Perspective for the Future. Cell. Mol. Life Sci. 62: 1707-1723.

Ferrer SA, Rodrygez-Lopez JN, Garcya-Carmona F. 1995. Tyrosinase: A Comprehensive Review of its Mechanism. Biochim. Biophys. Acta. 1247: 1-11.

Cabanes J, Chazarra S, Garcia CF. 1994. Kojic Acid, a Cosmetic Skin Whitening Agent, is a Slow Binding Inhibitor of Catecholase Activity of Tyrosinase. J Pharm. Pharmacol. 46(12): 982-985.

Reji AF, Alphonse NR. 2013. Phytochemical Study on Sesbania grandiflora. J of Chemical and Pharmaceutical Res. 5(2): 196-201.

Pandey A, Tripathi S. 2014. Concept of Standardization, Extraction and Pre Phytochemical Screening Strategies for Herbal Drug. J of Pharmacognosy and Phytochemistry. 2(5): 115-119.

Curto E.V, C. Kwong, H. Hermersdorfer, H. Glatt, C. Santis et al. 1999. Inhibitors of Mammalian Melanocyte Tyrosinase: In Vitro Comparisons of Alkyl Esters of Gentisic Acid with other Putative Inhibitors. Biochem. Pharmacol. 57: 663-672.

Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S. 2003. Glabrene and Isoliquiritigenin as Tyrosinase Inhibitors from Licorice Roots. J Agric Food Chem. 51: 1201-1207.

Seo S.Y, Sharma V.K, Sharma N. 2003. Mushroom Tyrosinase: Recent Prospects. J Agric Food Chem. 51: 2837-2853.

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Published

2016-12-07

How to Cite

Rayendra, R., Wientarsih, I., P. Priosoeryanto, B., & Gunawan, H. (2016). Potency of Jack Fruit Leaves as Tyrosinase Inhibitor. International Journal of Sciences: Basic and Applied Research (IJSBAR), 30(4), 351–357. Retrieved from https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/6622

Issue

Vol. 30 No. 4 (2016)

Section

Articles

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