Mathematical Modeling of the Transmission Dynamics of Ebola Virus Disease with control Strategies
Keywords:
Ebola virus, therapeutic treatment, reproductive number, Education campaign, Safe burial.Abstract
In this paper we develop a deterministic compartmental mathematical model for the spread of the Ebola virus disease (EVD) in the community. Our model incorporates education campaigns, quarantine, safe burial and therapeutic treatment as control strategies to bring the disease to an end. We derived the effective reproductive number for the model, and proved the stability of equilibrium points. We performed numerical simulations of the model and our results show that all control measures under consideration have an effect of decreasing severity of the epidemic when constantly administered. Furthermore, we found that reducing the number of contacts with infectious individuals in the general population is the most effective intervention method for mitigating an EVD epidemic.
References
Jane H. From pigs to monkeys, Ebola goes airborne. The Disease Daily. 2012 Nov 21 [Internet]. Available
from:http://healthmap.org/site/diseasedaily/article/pigs-monkeys-ebolagoes-airborne-112112[accessed
12.01].
Leroy, E. M., Kumulungui, B. & Pourrut, X. et al,
H. Feldmann and T.W. Geisbert,
Peters, C. J. & Peters, J. W,
Pourrut, X., Kumulungui, B. & Wittmann, T. et al,
Legrand, J., Grais, R. F. & Boelle, P. Y. et al,
Acha, P. N., and Szyfres, B,
Ebola virus disease fact sheet. Tech. rep., World Health Organization, April 2015.
Centers for Disease Control, Atlanta, GA, World Wide Web Page,
http:www.cdc.gov/ncidod/diseases/virlfvr/ebolainf.ht
Lewnard, Joseph A. et al.
Liberia: a mathematical modelling analysis. Lancet Infectious Diseases 14, 1189
Kupferschmidt, K,
Sifferlin A, Alterman A, Baker A et al,
Sankarankutty S, Mekaru S,
Bakare EA., and Nwagwo A. Danso-Addo, E. "Optimal control analysis of an SIR epidemic model with constant recruitment.
F.B. Agusto, M.I. Teboh-Ewungkem, and A.B. Gumel,
B. Ivorra, D. Ngom, and A.M. Ramos,
K. Bibby, L.W. Casson, E. Stachler, and C.N. Haas,
P. Francesconi, Z. Yoti, S. Declich, P.A. Onek, M. Fabiani,J. Olango, R. Andraghetti, P.E. Rollin,C. Opira, D. Greco, and S. Salmaso,
E.M. Leroy, P. Rouquet,P. Formenty, S. Souqui
E.M. Leroy, B. Kumulungui, X. Pourrut, P. Rouquet, A. Hassanin, P. Yaba, A. D
T.J. Piercy, S.J. Smither, J.A. Steward, L. Eastaugh, and M.S. Lever,
D. Youkee, C.S. Brown, P. Lilburn, N. Shetty, T. Brooks, A. Simpson, N. Bentley, M. Lado, T.B. Kamara, N.F.Walker, and O. Johnson,
S. Mushayabasa,
Rivers CM, Lofgren ET, Marathe M, Eubank S and Lewis BL,
Xia, Z.-Q. et al,
Van den Driessche, P and Watmough, J,
O.Diekmann, J. A. P. Heesterbeek and M. G. Roberts,
Stephen, E.,
Stephen, E, Nyerere, N,
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